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Journal of Arthropod-Borne Diseases، جلد ۱۷، شماره ۴، صفحات ۱۶۵۵-۱۶۵۵
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عنوان انگلیسی In Vitro Assessment of the Anti-Proliferative and Anti-Viability Effects of Salivary Gland Extracts from Hyalomma ticks (Acari: Ixodidae) on Human Colorectal Cancer Cells
چکیده انگلیسی مقاله Background: The saliva and salivary glands of ticks possess a wide range of immuno-pharmacologically active mole­cules that effectively modulate the activity of enzymes, antibodies, and amines that have a role in different biological processes. Derived components from saliva and salivary glands of hard ticks Ixodidae have been characterized as poten­tial natural sources for discovering promising anti-cancer drug candidates. Methods: The anti-cancer activity of salivary gland extracts (SGEs) from Hyalomma anatolicum, Hyalomma drome­darii, Hyalomma marginatum, and Hyalomma schulzei was assessed. MTT assays and flow cytometry were done on the HT-29 colorectal cancer cell line to evaluate the anti-viability and proliferative inhibition. Results: Based on the MTT assay results, the SGEs from Hy. dromedarii had the highest and lowest substantial anti-viability effects on the HT-29 cancer cell and human foreskin fibroblast (HFF) normal cell, respectively. The cytometric assessment revealed a significant increase in the apoptosis and necrosis ratio of the HT-29 cancer cells after treatment with Hy. dromedarii SGEs. Conclusion: The results demonstrated that Hy. dromedarii SGEs have significant anti-proliferative, anti-viability, and apoptotic potential. The result of this study suggests that Hy. dromedarii SGEs is an appropriate candidate for further investigations to identify and purify the mechanisms and molecules involved in the anti-cancer activity of the SGEs.
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نویسندگان مقاله | Maryam Tavassoli
Department of Vector Biology and Control of Diseases, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Mehdi Kadivar
Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran


| Amir Ahmad Akhavan
Department of Vector Biology and Control of Diseases, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Mohammad Abdigoudarzi
3Department of Veterinary Parasitology, Razi Vaccine and Serum Research Institute, Karaj, Iran


| Abbas Moridnia
Department of Genetics and molecular biology, School of Medicine, Dezful University of Medical Sciences, Dezful, Iran


| Samira Chaibakhsh
Eye Research Center, the Five Senses Institute, Iran University of Medical Sciences, Tehran, Iran


| Mojtaba Beik-mohammadi
West Health Center, Iran University of Medical Sciences, Tehran, Iran


| Mohammad Mehdi Sedaghat
Department of Vector Biology and Control of Diseases, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://jad.tums.ac.ir/index.php/jad/article/view/1655
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