| چکیده انگلیسی مقاله |
Introduction: Postpartum hemorrhage (PPH) is one of the main causes of maternal mortality. The present study was conducted with aim to investigate the relationship between low levels of fibrinogen and the severity of PPH and the importance of administering fibrinogen concentrate or cryo to reduce bleeding.Methods: This prospective cohort study was conducted from 2017 to 2019 on 122 mothers with uterine bleeding in the first 24 hours after delivery in Mashhad. In case of persistent bleeding and rejection of traumatic causes, misoprostol was prescribed, and blood samples were taken at this time (time H0). Patients were divided into severe and non-severe groups by considering the severity of bleeding from H0 to 24 hours. Data were analyzed by SPSS software (version 16) and independent t-test and Mann-Whitney, paired t, Chi-square and Fisher's tests. P<0.05 was considered statistically significant.Results: Of 122 mothers, 38 and 84 were in the severe and non-severe groups, respectively. More than 50% of the mothers had a normal delivery, and there was no significant difference between the two groups in terms of delivery method (p=0.883). Postpartum fibrinogen level in H0 was significantly lower in the severe group compared to the non-severe group (p<0.001). The mean fibrinogen level was 274.8±115.8 mg/dL in the severe and 368.4±78.5 mg/dL in the non-severe groups.Conclusion: Early administration of products containing fibrinogen can help to reduce the amount of bleeding in case of PPH and thus reduce the number of bleeding complications and possible interventions. In future studies along with increasing the sample volume, sampling 12 and 24 hours after delivery is also suggested to control the level of fibrinogen. |
| نویسندگان مقاله |
دکتر سارا خشخاشی مقدم | Sara Khashkhashi Moghaddam
Anesthesiologist, Department of Anesthesiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
متخصص بیهوشی، گروه بیهوشی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
دکتر مصطفی قاسم پور | Mostafa Ghasempour
Specialist of Otorhinolaryngology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
متخصص گوش و حلق و بینی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
دکتر شهریار نوروزپور | Shahriar Norouzpour
Specialist of Pathology, Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
متخصص پاتولوژی، گروه پاتولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
دکتر مهرداد مکرم دری | Mehrdad Mokarram Dori
Assistant Professor, Department of Anesthesiology and Pain Center, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
استادیار گروه بیهوشی، گروه بیهوشی و مرکز درد، بیمارستان امام رضا (ع)، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
دکتر نگار مروت دار | negar morovatdar
Assistant Professor, Department of Socio-Medicine, Clinical Research Development Unit, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
استادیار گروه پزشکی اجتماعی، واحد توسعه تحقیقات بالینی بیمارستان امام رضا (ع)، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
سحر شهبازی | Sahar Shahbazi
B.Sc. of Anesthesiology, Department of Anesthesiology and Pain, Emam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
کارشناس بیهوشی، گروه بیهوشی و درد، بیمارستان امام رضا (ع)، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
زهره فیضی | Zohreh Feizi
B.Sc. of Anesthesiology, Department of Anesthesiology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
کارشناس بیهوشی، گروه بیهوشی، بیمارستان قائم (عج)، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
دکتر ناصر نادری | Naser Naderi
Anesthesiologist, Department of Anesthesiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
متخصص بیهوشی، گروه بیهوشی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
دکتر سیده حورا موسوی واحد | Seyyede Houra Mousavi Vahed
Assistant Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
استادیار گروه زنان و مامایی، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
دکتر ناهید زیرک | Nahid Zirak
Associate Professor, Department of Anesthesiology, Lung Disease Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
دانشیار گروه بیهوشی، مرکز تحقیقات بیماری‌های ریه، دانشکده پزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران.
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