این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Chemistry and Chemical Engineering، جلد ۴۱، شماره ۲، صفحات ۴۵۵-۴۶۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Unveiling the Full Potential of 2-aryl-1H-phenanthro [9,10-d] imidazoles as Cytotoxic Agents vs AGS, HepG2 and MCF-7 Cell lines
چکیده انگلیسی مقاله A few 2-aryl-1H-phenanthro [9,10-d] imidazoles were synthesized and assessed for their cytotoxicity against MCF-7, HepG2, and AGS cell lines using MTT assay. Cellular assessments showed that phenanthroimidazoles were extremely potent cytotoxic agents (sub-nanomolar IC50s). Maximum effect was recorded for para-N-phenyl acetamide containing derivative against AGS cells (IC50 0.07 nM). It was also revealed that phenanthroimidazole derivatives showed better cytotoxicity against MCF-7 and AGS cells when compared to HepG2 cells. Minimum cytotoxicity was reported for para-methylphenyl derivatives within HepG2 cancer cells (IC50 7608.07 nM). Structure-activity relationship studies indicated that incorporation of nitrogen/oxygen-containing polar groups such as N-acetyl or nitro into para/meta positions of phenyl ring significantly enhanced the cytotoxicity against AGS cells. A similar trend was observed in meta-nitro derivatives vs MCF-7 cells. It was revealed that even the least potent compound exhibited cytotoxic activity in the range of low micromolar IC50. Results of this study proposed 2-aryl-1H-phenanthro [9,10-d] imidazoles as privileged structures for further in vivo studies.
کلیدواژه‌های انگلیسی مقاله Cancer,Cytotoxicity,Phenanthroimidazole,AGS, HepG2, MCF-7
نویسندگان مقاله Mohammad Kazem Mohammadi |
Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, I.R. IRAN

Shahab Bohluli |
Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, I.R. IRAN

Ali Javid |
Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, I.R. IRAN

Haman Tavakkoli |
Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, I.R. IRAN

Amir Ghorbanpour |
Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, I.R. IRAN

Nima Razzaghi Asl |
Department of Medicinal Chemistry, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, I.R. IRAN

نشانی اینترنتی https://ijcce.ac.ir/article_245908_5e0b94b0b9f571ddb73ee7c05c29800e.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات