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Iranian Journal of Chemistry and Chemical Engineering، جلد ۴۱، شماره ۱۲، صفحات ۴۱۸۰-۴۱۹۲
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عنوان انگلیسی Synthesis of Aureobasidin B Analogs and Their Antifungal Activity Against Candida albicans
چکیده انگلیسی مقاله Aureobasidins (Abs) are a class of cyclodepsipeptides with interesting antifungal properties but they are difficult to synthesize. This study aimed to synthesize analogs of aureobasidin B (AbB) by a combination of solid- and solution-phase synthesis and to investigate their antifungal properties. The linear peptides were synthesized on 2-chlorotrityl chloride resin with Fmoc strategy and a range of coupling reagents including HATU/HOAt, HBTU/HOBt, and BTC/sym-collidine. The cyclization step was undertaken in the solution phase. Four cyclic nonapeptides (NP1-NP4) and ten cyclic heptapeptides (HP1-HP2, HP4-HP11) were successfully synthesized and characterized. The analogs NP1, NP4, HP1, and HP2 demonstrated moderate antifungal activity against Candida albicans
کلیدواژه‌های انگلیسی مقاله Aureobasidin B,Cycloheptapeptides,Cyclononapeptides,solid-phase peptide synthesis
نویسندگان مقاله Rani Maharani |
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, West Java, INDONESIA

Ace Tatang Hidayat |
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, West Java, INDONESIA

Ace Tatang Hidayat |
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, West Java, INDONESIA

Desi Harneti |
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, West Java, INDONESIA

Ika Wiani |
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, West Java, INDONESIA

Nurlelasari Nurlelasari |
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, West Java, INDONESIA

Unang Supratman |
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, West Java, INDONESIA

نشانی اینترنتی https://ijcce.ac.ir/article_706605_27544b9f3155bd92626ccc92d6e014e4.pdf
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