|
|
Iranian Journal of Dermatology، جلد ۲۵، شماره ۳، صفحات ۲۲۱-۲۲۹
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Efficacy assessment of topical brimonidine 0.33% in the treatment of rosacea in Middle Eastern patients with darker skin types |
|
| چکیده انگلیسی مقاله |
Background: Brimonidine tartrate is an alpha-2 adrenergic receptor agonist approved for treating rosacea. This study aimed to assess the efficacy and safety of a brimonidine gel in rosacea patients with skin types III and IV. Methods: This study was a phase II before-after clinical study in 20 patients with moderate to severe rosacea treated with brimonidine 0.33% gel. Clinician’s Erythema Assessment (CEA), Patients’ Self-Assessment (PSA), skin erythema (ΔE), lightness (ΔL), and biophysical parameters were measured before treatment and 4 and 8 weeks later. Ultrasound parameters were also measured at the same time points. Results: Eighteen patients completed the study. CEA and PSA decreased significantly from 3.05 to 2.10 and 2.15 after 4 weeks and 2.20 and 2.15 after 8 weeks, respectively (P<0.01 for both). Furthermore, ΔE and ΔL, as well as the skin erythema index, improved after 4 weeks of treatment. The skin echo density of both the epidermis and dermis also increased after 8 weeks (P<0.05). During the study, no serious adverse events occurred other than some reports of temporary moderate redness. Conclusion: Daily application of brimonidine 0.33% gel is safe and effective for the treatment of rosacea in darker skin types. |
|
| کلیدواژه‌های انگلیسی مقاله |
brimonidine,rosacea,Middle Eastern People,biophysical parameters |
|
| نویسندگان مقاله |
Saman Ahmad Nasrollahi |
Center for Research & Training in
Skin Diseases & Leprosy, Tehran
University of Medical Sciences,
Tehran, Iran
Aniseh Samadi |
Center for Research & Training in
Skin Diseases & Leprosy, Tehran
University of Medical Sciences,
Tehran, Iran
Fatemeh Samii |
Pharmaceutical Sciences Branch,
Islamic Azad University, Tehran, Iran
Chao Yuan |
Skin & Cosmetic Research
Department, Shanghai Skin Disease
Hospital, Shanghai, China
Alireza Firooz |
Center for Research & Training in
Skin Diseases & Leprosy, Tehran
University of Medical Sciences,
Tehran, Iran
|
|
| نشانی اینترنتی |
https://www.iranjd.ir/article_164128_3bebf54946696fedf5e242e5e12627d0.pdf |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
|
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|