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International Journal of Fertility and Sterility، جلد ۱۷، شماره ۳، صفحات ۱۸۷-۱۹۴
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عنوان انگلیسی The Effects of Clove Oil on The Biochemical and Histological Parameters, and Autophagy Markers in Polycystic Ovary Syndrome-Model Rats
چکیده انگلیسی مقاله Background: This study aimed to determine whether syzygium aromaticum (clove) could help polycystic ovary
syndrome (PCOS) rats.
Materials and Methods: In this experimental study, forty adult female Wistar rats (weighing 250 ± 10 g) were divided
randomly into five groups; G1: control, G2: PCOS group, G3: PCOS+clove (30 mg/kg/ orally/daily) group, G4:
PCOS+clove (60 mg/kg/orally/daily) group, and G5: PCOS+gonadectomy group. The PCOS was induced by a single
dose injection of estradiol valerate (16 mg/kg/IM). Following PCOS induction, the rats were treated for 14 days. Histological
parameters, follicle apoptosis, mRNA expression of autophagy markers (Lc3, Beclin1), oxidative stress markers,
insulin and blood glucose levels, as well as serum levels of aromatase and testosterone were evaluated in these rats.
Finally, the ratio of serum luteinizing hormone (LH) to follicle-stimulating hormone (FSH) levels was also calculated.
Results: The autophagy markers (Lc3, Beclin1), histological parameters, oxidative stress, insulin, and hormone levels
changed significantly in the PCOS rats (G2). In G3 and G5 groups, it was observed that the levels of LH/FSH and testosterone
decreased significantly in comparison to the PCOS group, and inhibition of autophagy was also observed in
these groups. Treatment with cloves in the G3 group significantly improved oxidative stress, histological parameters,
and insulin levels.
Conclusion: These findings demonstrated that oxidative stress, apoptosis, and excessive autophagy could be improved
by treatment with low doses of clove and gonadectomy. Cloves may help to improve these parameters by regulating and
inhibiting excessive autophagy. However, discovering the direct role of this extract in regulating the parameters such
as oxidative stress, insulin, and androgens requires further investigation. In the present study, P<0.05 was considered
statistically significant.
کلیدواژه‌های انگلیسی مقاله Apoptosis, autophagy, Oxidative stress, Polycystic Ovary Syndrome, Syzygium Aromaticum (clove)
نویسندگان مقاله Malihe Soltani |
Department of Basic Sciences, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran

Maryam Moghimian |
Department of Basic Sciences, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran

Seyd-Hosein Abtahi-Evari |
Department of Basic Sciences, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran

Seyed-Alireza Esmaeili |
Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Ramin Mahdipour |
Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Majid Shokoohi |
Clinical Research Development Unit of Tabriz Valiasr Hospital, Tabriz University of Medical Sciences, Tabriz, Iran

نشانی اینترنتی https://www.ijfs.ir/article_696653_60bdf1aed37ef0cb93a3aab7b04aee1d.pdf
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