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Iranian Journal of Microbiology، جلد ۱۵، شماره ۶، صفحات ۸۱۱-۸۲۰
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عنوان انگلیسی Synthesis of new imidazole-based ionic liquids with antifungal activity against Candida albicans
چکیده انگلیسی مقاله Background and Objectives: Candida albicans cause a problematic condition in immunocompromised patients that could not be treated quickly due to the resistant behavior of microorganisms. This study aimed to investigate the effect of a novel ionic liquid (IL) as a new drug on C. albicans strains. Materials and Methods: Seven newly binary ionic liquids mixtures were synthesized, and among them, ([prollinium chloride] [1-methylimidazolium 3-sulfonate] ([pro-HCl][MImS]) was selected and characterized by 1HNMR, 13C NMR, and FT-IR methods. Samples from patients (n=50) with candidiasis were collected and identified through culture media. ERG11 gene overexpression was related to resistance against azole-bearing drugs. The antibiogram, well diffusion assay, MICs, and MFCs tests were operated. PCR and Real-time evaluated the expression of the ERG11 gene, and the rate of cell death was detected using Flow Cytometry. Results: Our data manifested that this novel IL (Ionic Liquid) can inhibit C. albican's growth, reduce the expression of ERG11 and increase dead cells. Conclusion: The newly synthesized IL had an inhibiting effect on the growth of the C. albicans strains and may be used as an alternative candidate for novel drug design.
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نویسندگان مقاله | Amir Habibi
Department of Pathobiology, Faculty of Veterinary Science, Science and Research Branch, Islamic Azad University, Tehran, Iran


| Mansour Bayat
Department of Pathobiology, Faculty of Veterinary Science, Science and Research Branch, Islamic Azad University, Tehran, Iran


| Behinb Omidi
Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran


| Ali Ezabadi
Department of Chemistry, Faculty of Science, Central Tehran Branch, Islamic Azad University, Tehran, Iran


| Pejman Mortazavi
Department of Pathobiology, Faculty of Veterinary Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/4183
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