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Iranian Journal of Microbiology، جلد ۱۵، شماره ۶، صفحات ۸۰۳-۸۱۰
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عنوان انگلیسی Persistence of SARS-CoV-2-antibodies against N, S and RBD after natural infection
چکیده انگلیسی مقاله Background and Objectives: Coronavirus disease 2019 (COVID-19) pandemic has affected most countries in the world. Monitoring the humoral immune responses during the natural course of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection and the duration of them provide useful information for the development of vaccination strategies against this virus and its emerging variants. The importance of the antibody response especially neutralizing antibodies in long-term immunity to SARS-CoV-2 is significant. Materials and Methods: The present study is a cross-sectional study of sero-epidemiological type that has been proposed to compare the persistence of Immunoglobulin G (IgG) against N (nucleocapsid), S (spike) and RBD (receptor-binding domain) proteins in the community after the time of primary disease. A total of 652 serum samples were collected from hospital staff working in COVID wards, as well as a number of community members with different occupations, among those with positive antibody titers, 86 participated in the resampling test before vaccination. Results: There was no association between antibody titer and disease severity (p>0.05). A significant decrease in Ab levels was observed in the paired second samples. The highest rate of decrease was related to anti-N, then anti-RBD and anti-S IgG levels, respectively. There is a significant relationship between the initial antibody titer and its reduction over time (p-value < 0.05). Conclusion: Our data revealed that humoral immunity following natural infection of SARS-CoV-2 is detectable for at least 4 months, regardless of disease severity. The most decrease in antibody titer over time was related to anti-N IgG levels.
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نویسندگان مقاله | Mitra Jafari
Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran


| Samira Asli
Clinical Research Development, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Fateme Moghbeli
Department of Health Information Technology, Varastegan Institute for Medical Sciences, Mashhad, Iran


| Mohammad Gholami Fesharaki
Department of Statistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran


| Nazila Hajiahmadi
Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran


| Faezeh Mojtahedzadeh
Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran


| Saeid Amel Jamehdar
Clinical Research Development, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Taravat Bamdad
Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/4040
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