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مجله بین المللی کودکان و نوجوانان، جلد ۲، شماره ۳، صفحات ۲۹-۳۱
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Amiloride vs hydrochlorthiazide therapy in children with nephrotic syndrome: A clinical trial |
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| چکیده انگلیسی مقاله |
Background and Objective: To assess the effectiveness and safety of oral amiloride for the treatment of edema in pediatric patients with idiopathic nephrotic syndrome. Methods: A randomized trial of amiloride vs hydrochlorthiazide was done in 34 patients. The mean age was 4.3±0.7 years old. After a 2 week washout of diuretic therapy, nephrotic children with edema were randomized into two groups receiving amiloride vs hydrochlorthiazide. The effect of diuretics was assessed by the amount of weight reduction and the measurement of urinary fractional excretion of sodium during the first three days of diuretic therapy. The primary end point was the decrease in body weight. Findings: Of 34 patients enrolled for this trial, 17 patients were in amiloride group and 17 patients in hydrochlorthiazide group. The mean weight loss during the first three days of diuretic therapy was 1.3±0.65 kg in amiloride group and 1.19±0.4 kg in hydrochlorthiazide group (PV=0.55). The mean of maximum urinary fractional excretion of sodium during the first three days of diuretic therapy was 2.1±0.65% in amiloride group and 1.8±1% in hydrochlorthiazide group. Conclusion: There was not any difference between amiloride and hydrochlorthiazide medications in reducing weight and increasing urinary fractional excretion of sodium in children with nephrotic syndrome. |
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| کلیدواژه‌های انگلیسی مقاله |
Amiloride, hydrochlorthiazide, Children, Nephrotic syndrome |
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| نویسندگان مقاله |
سهیلا مهدوی نیا | soheila mahdavinia
iran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
حسن اتوکش | hasan otukesh
iran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
رزیتا حسینی | rozita hoseini
iran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
مهرداد shheikhvatan | mehrdad shheikhvatan
iran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
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| نشانی اینترنتی |
http://ijca.iums.ac.ir/browse.php?a_code=A-10-1-46&slc_lang=fa&sid=en |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/1929/article-1929-290696.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
عمومی |
| نوع مقاله منتشر شده |
پژوهشی |
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