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مجله بین المللی کودکان و نوجوانان، جلد ۲، شماره ۳، صفحات ۶-۱۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Early and late outcome of treatment with oral ibuprofen in preterm infants suffering from patent ductus arteriosus: A randomized clinical trial |
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| چکیده انگلیسی مقاله |
Background and Objective: Nonsteroidal anti-inflammatory agents are the treatment of choice for ductal closure in premature newborn. This study evaluates early and late outcome, as well as the effectiveness of oral ibuprofen in the treatment of patent ductus arteriosus (PDA) in premature infants. Methods: In this clinical trial, all preterm infants below 37 weeks, with documentation of PDA were enrolled Infants were divided into two groups. The case group (19 patients) was treated with three doses of oral ibuprofen. Control group (19 patients) were under restriction of fluids (serum level of ⅔ maintenance). The rate of ductal closure, presence of pulmonary hypertension were determined at the age of one week, one month, 3 months and 6 months and intraventricular hemorrhage and periventricular leukomalacia (PVL) were detected at the age of one week and one month. The presence of retinopathy was checked at the time of hospital discharge and at the age of one month. Results: Ductal closure was achieved in all newborn of the ibuprofen group whereas in control group ductal closure rate was 16.19 (84.2%) (p=0.23). No case of pulmonary hypertension, PVL or retinopathy was observed in oral ibuprofen group. Regarding to other criteria such as hospital stay, intraventricular hemorrhage, sepsis, ventilator time dependence, pulmonary hemorrhage and mortality rate, no significant difference between the two groups was observed. Conclusions: Oral ibuprofen suspension may be an effective and safe alternative for PDA closure in premature infants. However larger studies are warranted. |
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| کلیدواژه‌های انگلیسی مقاله |
Oral ibuprofen, Patent ductus arteriosus, Premature infants |
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| نویسندگان مقاله |
سمیرا مهرعلیزاده | semira mehralizadeh
semnan university of medical sciences, semnan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی سمنان (Semnan university of medical sciences)
غلامرضا دارایی | gholamreza daraee
semnan university of medical sciences, semnan, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی سمنان (Semnan university of medical sciences)
راهب قربانی | raheb ghorbani
semnan university of medical sciences, semnan, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی سمنان (Semnan university of medical sciences)
زکیه انتظاری نسب | zakieh entezari nasab
semnan university of medical sciences, semnan, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی سمنان (Semnan university of medical sciences)
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| نشانی اینترنتی |
http://ijca.iums.ac.ir/browse.php?a_code=A-10-1-41&slc_lang=fa&sid=en |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/1929/article-1929-290692.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
عمومی |
| نوع مقاله منتشر شده |
پژوهشی |
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