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Iranian Journal of Basic Medical Sciences، جلد ۲۶، شماره ۱۲، صفحات ۱۴۴۹-۱۴۵۹
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Effect of resistance and endurance training with ursolic acid on oxidative stress and cognitive impairment in hippocampal tissue in HFD/STZ-induced aged diabetic rats |
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| چکیده انگلیسی مقاله |
Objective(s): The increase in age-related cognitive impairment (CIs) and diabetes mellitus is a global health concern. Exercise training has been reported to activate the Nrf2/Keap1/ARE signaling and enhance the antioxidant defense pathways in some animal models. This study aimed to investigate the effects of ursolic acid (UA) associated with resistance or endurance training on antioxidant markers, and the Nrf2/Keap1/ARE pathway in the brain of older diabetic rats.Materials and Methods: 23-month-aged diabetes induced male Wistar rats were randomly assigned to seven groups (n=8). UA supplementation (250 mg/kg, daily) was administered along with resistance (60% maximum capacity of voluntary carrying [MVCC], 14-20 climbs) or endurance training (60-75% velocity at maximal oxygen uptake [vVO2max]), five days/week for eight weeks. Cognitive-motor functioning was assessed through open-field and passive avoidance response tests. Nrf2, Keap1, and antioxidant markers including SOD, CAT, GPx, and GSH were measured in the hippocampus tissue.Results: The results showed positive effect of resistance training (P≤0.001) on Nrf2. There was endurance training with supplementation main effect (P=0.018) on Keap1 concentration. SOD revealed a significant endurance/resistance training by supplementation interaction effect (P≤0.05); however, there was no main training or UA supplementation effects on CAT, GPx, and GSH, despite improving spatial memory changes in exercise or UA groups. Conclusion: It appears that UA treatment with resistance or endurance exercise has some beneficial effects on Nrf2 and some antioxidant markers. However, more research is needed to elucidate UA’s interaction effects and exercise interventions in diabetic situations. |
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| کلیدواژه‌های انگلیسی مقاله |
Cognitive impairment, Diabetes, Hippocampus, Nrf2/Keap1/ARE signaling, Training, Ursolic acid |
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| نویسندگان مقاله |
| Safoura Alizade
Department of Sport Sciences, Shahrekord University, Shahrekord, Iran
| Mohammad Faramarzi
Department of Exercise Physiology, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran
| Ebrahim Banitalebi
Department of Sport Sciences, Shahrekord University, Shahrekord, Iran
| Elham Saghaei
Department of Pharmacology, Shahrekord University of Medical Sciences, Shahrekord, Iran
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| نشانی اینترنتی |
https://ijbms.mums.ac.ir/article_22901.html |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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