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Iranian Journal of Microbiology، جلد ۱۵، شماره ۵، صفحات ۶۱۶-۶۲۴
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عنوان انگلیسی Characterization of integrons, extended spectrum beta lactamases and genetic diversity among uropathogenic Escherichia coli isolates from Kerman, south east of Iran
چکیده انگلیسی مقاله Background and Objectives: The study aimed to investigate the distribution of genes encoding integrons, extended spectrum beta-lactamase (ESBL) in E. coli isolated from UTIs, as well as the genetic diversity among the isolates. Materials and Methods: E. coli isolates were recovered from the patients with UTI in Kerman Iran. Antibiotic susceptibility was done according to CLSI guidelines. The presence of ESBL genes and integrons was evaluated using PCR. PCR and sequencing were applied for the evaluation of cassette content of integrons. Genotyping of the isolates was performed by multiple-locus variable-number tandem repeat analysis (MLVA). Results: Imipenem was the most effective antibiotic, while the highest resistance was observed to streptomycin. In total 40.2% of isolates were ESBL producers. Of 69 integron-positive isolates, 59 only had class I integrons, 4 only had class II integrons and 6 had both types. The most common gene cassette found within class I integrons was dfrA17-aadA5 (n=27). The E. coli isolates were divided into 16 MLVA clusters. Conclusion: The current study demonstrated the simultaneous presence of class I integrons and ESBLs involved in the resistance of UPEC isolates to antibacterial agents. Our finding also revealed that the E. coli isolates belonged to diverse clones.
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نویسندگان مقاله | Samane Mohebi
Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran


| Zahra Golestani-Hotkani
Department of Biosciences, University of Milan, Milan, Italy


| Maryam Foulad-Pour
Clinical Research Development Unit, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran


| Peivand Nazeri
Clinical Research Development Unit, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran


| Fahimeh Mohseni
Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran


| Zahra Hashemizadeh
Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran


| Zahra Moghani-Bashi
Clinical Research Development Unit, Shahid Bahonar Hospital, Kerman University of Medical Sciences, Kerman, Iran


| Naser Niksefat
Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran


| Sanaz Rastegar
Medical Mycology and Bacteriology Research Center, Kerman University of Medical Sciences, Kerman, Iran


| Maryam Khajedadian
Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran


| Zahra Lotfian
Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran


| Hossein Hosseini-Nave
Medical Mycology and Bacteriology Research Center, Kerman University of Medical Sciences, Kerman, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/4157
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