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Nanomedicine Journal، جلد ۱۰، شماره ۴، صفحات ۳۱۳-۳۲۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Investigation and comparison of laser and ultrasound effects on the temperature increasing of the solutions containing graphene oxide nanoparticles for thermal treatment of osteosarcoma cancer cells
چکیده انگلیسی مقاله Objective(s): The waves of ultrasound and laser in the presence of nanoparticles are introduced as desirable candidates for the thermal treatment of cancer due to having fewer side effects, more speed, and superior treatment efficiency. Here, 2D Graphene oxide nanoparticle is used as a thermal nano-convertor for increasing the yield of thermal cancer therapy.Materials and Methods: The temperature of GO (in 0.2 and 0.4 mg/ml concentrations) and deionized water regarding heater, bath sonicate, probe sonicate (at a power range of 2-3.5 W), and laser properties at 808 nm with continuous wave (at a power of 0-2 W) in 10 min are investigated. Based on the experimental results, the effect of laser and ultrasound radiation on the temperature is simulated using a data mining approach.Results: Experimental and simulation results show that GO nanoparticle in this form is unsuitable for converting ultrasound waves into heat. But it is a strong absorber for electromagnetic waves at 808 nm and can raise the temperature to 85 °C. The results indicate that the laser + GO enhances the mortality percentage and treatment yield of MG63 cancerous cells by up to 85%. Also, GO uptake is analyzed by fluorescent microscopic images.Conclusion: This analysis confirmed that GO is important when laser radiation is used but not when Ultrasound is employed. Also, GO is an excellent photothermal nanoparticle for localized thermal therapy of osteosarcoma cancer cells by laser at 808 nm with low side effects.
کلیدواژه‌های انگلیسی مقاله Cancer, Graphene oxide, Laser, Thermal Therapy, Ultrasound
نویسندگان مقاله | Najmeh Sadat Hosseini Motlagh
Department of Biomedical Engineering, Meybod University, PO Box 89616-99557, Meybod, Iran


| Elyas Sharifi
Department of Biology, Taft Payame Noor University, Yazd, Iran


| Bibi Fatemeh Hghiralsadat
Department of Advanced Medical Sciences and Technologies, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


| Mohsen Sardari Zarchi
Department of Computer Engineering, Meybod University, Meybod, Iran


| Fatemeh Yaghoubi
Department of Nursing, Shirvan Faculty of Nursing, North Khorasan University of Medical Sciences, Bojnūrd, Iran


| Fatemeh Oroojalian
Department of Advanced Technologies, School of Medicine, North Khorasan University of Medical Sciences, Bojnūrd, Iran|Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnūrd, Iran
نشانی اینترنتی https://nmj.mums.ac.ir/article_23117.html
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