Middle East Journal of Digestive Diseases، جلد ۱۵، شماره ۳، صفحات ۱۹۶-۲۰۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The Seroprevalence of Hepatitis A in Patients with Positive Human Immunodeficiency Virus
چکیده انگلیسی مقاله Background: Hepatitis A virus ( HAV ) can have severe manifestations in adult patients with other liver diseases, particularly in those infected with human immunodeficiency virus ( HIV ). This study aimed to measure immunity against HAV in HIV -positive individuals to determine the necessity of vaccination against HAV in this population. Methods: This cross-sectional study investigated 171 HIV -positive patients aged 18 years or older who were tested for serum IgG anti-viral hepatitis A antibody. The prevalence and its determinants were analyzed based on patient data. Result: The average age of the patients was 44.2 years old. The prevalence of HAV antibody positivity was 97.7%. The prevalence was higher in patients older than 30 years. There was a close association between hepatitis C virus ( HCV ) infection (p = 0.002). There were no significant correlations between antibody levels and sex, marital status, employment status, education level, economic status, smoking status, drug use status, and physical activity level. The mean and median CD4+ counts in patients with positive (reactive) antibody (ABb) levels were 458 and 404 ± 294, respectively, while the mean and median CD4+ counts in patients with non-reactive antibody levels were 806 and 737 ± 137, respectively, in those who tested negative for anti- HAV Ab (P=0.05). Conclusion: The prevalence of anti-hepatitis A IgG antibodies in people with HIV was very high in Shiraz. There is an increasing trend in the number of older patients and those with HCV infections. The negative association with CD4 was borderline in this study, which needs to be confirmed in larger groups.
کلیدواژه‌های انگلیسی مقاله HAV, HIV, Seroprevalence, IgG
نویسندگان مقاله | Navid Omidifar
Department of Internal Medicine, School of Medicine, Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


| Kamran Bagheri Lankarani
Department of Medical Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran


| Mir Behrad Aghazadeh Ghadim
Department of Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran


| Nika Khoshdel
HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran


| Hassan Joulaei
HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran


| Parisa Keshani
Cellular and Molecular Biology Research Center, Larestan University of Medical Sciences, Larestan, Iran Student Research Committee, Larestan University of Medical Sciences, Larestan, Iran


| Seyyed Amirreza Saghi
Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


| Yousef Nikmanesh


نشانی اینترنتی http://mejdd.org/index.php/mejdd/article/view/2865
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات