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Research in Pharmaceutical Sciences، جلد ۱۸، شماره ۵، صفحات ۵۲۸-۵۴۰
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Formulation and evaluation of taste-masked oral disintegrating tablet containing tolterodine-loaded montmorillonite
چکیده انگلیسی مقاله Background and purpose: The present study aimed to obtain a taste-masked oral disintegrating tablet (ODT) containing tolterodine tartrate (TT) intercalated into montmorillonite (MMT) Experimental approach: The TT-MMT hybrid was prepared by ion exchange reaction. The effect of the initial concentration of TT, MMT, temperature, and pH on the encapsulation efficiency (EE) % of the drug in MMT was evaluated. The selected TT-MMT hybrid w::as char::acterized by X-ray diffraction (XRD), Fourier transforms infrared (FTIR), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM). Then, the optimized TT-MMT hybrid was incorporated in the ODT prepared by direct compression method and taste-masking assessment performed by a human test panel. Findings/Results: The EE% of TT was in the range of 22.67 to 71.06% in different formulations. It was found that increases in MMT concentration significantly increased EE%. DSC and XRD studies indicated that the TT was intercalated in the MMT interlayer space in an amorphous or molecular state. In-vitro release studies at pH 6.8 showed that the amount of the drug released from the TT-MMT hybrid was negligible for the first 3 min. The post-compression of ODT also showed satisfactory results in terms of friability, hardness, disintegration time, and taste. Conclusion and implications: MMT-ODT could be a suitable vehicle for the taste masking of TT, with the potential for use in patients with swallowing problems.
کلیدواژه‌های انگلیسی مقاله In vitro release,Montmorillonite k10,Orally disintegrating tablet,Tolterodine tartrate,Taste masking.
نویسندگان مقاله | Somayeh Taymouri
Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran. Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.


| Abolfazl Mostafavi
Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.


| Homa Talabaki


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/2210
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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