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Research in Pharmaceutical Sciences، جلد ۱۸، شماره ۵، صفحات ۵۱۷-۵۲۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Metabolomic identification of biochemical changes induced by fluoxetine in an insulinoma cell line (MIN6)
چکیده انگلیسی مقاله Background and purpose: The use of fluoxetine raises the risk of pancreatic beta-cell dysfunction. However, the specific mechanism behind its mechanism of action in beta cells is unknown. This study investigated the cellular response of MIN6 cells to fluoxetine using untargeted cell-based metabolomics. Experimental approach: Metabolic profiling of MIN6 cells was performed using liquid chromatography-high resolution mass spectrometry (LC-HRMS) analysis on samples prepared under optimized conditions, followed by principal component analysis, partial least squares-discriminant analysis, and pair-wise orthogonal projections to latent structures discriminant analyses. Findings/Results: Sixty-six metabolites that had been differentially expressed between the control and fluoxetine-treated groups demonstrated that the citric acid cycle is mainly perturbed by fluoxetine treatment. Conclusion and implications: The current study provides insights into the molecular mechanisms of fluoxetine effects in MIN6 cells.
کلیدواژه‌های انگلیسی مقاله Fluoxetine,High-resolution mass spectrometry,Insulinoma cell line,Liquid chromatography,Metabolomics.
نویسندگان مقاله | Surachai Ngamratanapaiboon
Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Dusit, Bangkok, 10300, Thailand.


| Krittaboon Pornchokchai
Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Dusit, Bangkok, 10300, Thailand.


| Siriphattarinya Wongpitoonmanachai
Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Dusit, Bangkok, 10300, Thailand.


| Petchlada Pholkla
Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Dusit, Bangkok, 10300, Thailand.


| Napatarin Srikornvit
Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Dusit, Bangkok, 10300, Thailand.


| Jiajun Mo
Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Dusit, Bangkok, 10300, Thailand.


| Patipol Hongthawonsiri
Department of Biomedical Engineering, Faculty of Engineering, Mahidol University, Salaya, Nakhon Pathom, 73170, Thailand.


| Pracha Yambangyang
Department of Medical Sciences, Ministry of Public Health, Nonthaburi, 1100, Thailand.


| Pilaslak Akrachalanont


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/2209
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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