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Research in Pharmaceutical Sciences، جلد ۱۸، شماره ۵، صفحات ۴۷۸-۴۸۸
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عنوان انگلیسی Anti-proliferative, anti-migration, and anti-invasion activity of novel hesperidin glycosides in non-small cell lung cancer A549 cells
چکیده انگلیسی مقاله Background and purpose: Several attempts have been made to synthesize and investigate modified flavonoids to improve their potential anticancer efficacy. This study aimed to determine the in vitro anti-viability, anti-migration, and anti-invasive effects of two novel hesperidin glycosides, hesperidin glucoside (HG 1 ) and hesperidin maltoside (HG 2 ), compared to original hesperidin and diosmin. Experimental approach: Inhibitory effects on normal (MRC5) and cancer (A549) cell viability of hesperidin glycosides were investigated by the trypan blue and MTS assays. A scratch assay determined the suppressive effects on cancer cell migration, and inhibition of cancer cell invasion was investigated through Matrigel™. The selectivity index (SI), a marker of cell toxicity, was also determined for A549 relative to MRC5 cells. Findings/Results: The cell viability trypan blue and MTS assays showed similar results of the inhibition of A549 cancer cells; HG 1 and HG 2 had lower IC 50 than original hesperidin and diosmin. The SI of HG 1 and HG 2 was > 2 after 72-h culture. Investigation of cell migration showed that HG 1 and HG 2 inhibited the ability of gap closure in a time- and dose-dependent manner. The infiltration of the Matrigel™-coated filter by A549 cells was suppressed in the presence of HG 1 and HG 2 . This result implied that HG 1 and HG 2 could inhibit cancer cell invasion. Conclusion and implication: Our results suggest the inhibition of cancer cell migration and invasion in a time- and concentration-related manner with a favorable toxic profile. Moreover, HG 1 and HG 2 appeared potentially better agents than the original hesperidin for future anticancer development.
کلیدواژه‌های انگلیسی مقاله Anticancer,Anti-invasion,Anti-migration,Anti-proliferation,Hesperidin glycosides.
نویسندگان مقاله | Natwadee Poomipark
Protein Research Laboratory, Division of Biochemistry, Department of Pre-Clinical Science, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand.


| Titaporn Chaisin
Protein Research Laboratory, Division of Biochemistry, Department of Pre-Clinical Science, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand.


| Jarunee Kaulpiboon


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/2206
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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