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Research in Pharmaceutical Sciences، جلد ۱۸، شماره ۵، صفحات ۴۶۸-۴۷۷
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چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Probiotic Lactobacillus and the potential risk of spreading antibiotic resistance: a systematic review
چکیده انگلیسی مقاله Background and purpose: Lactobacillus , the most popular probiotic, has recently gained more attention because it is a potential reservoir of antibiotic resistance. This review summarized and discussed the phenotypic-genotypic characteristics of antibiotic resistance. Experimental approach: Google Scholar, PubMed, Web of Science, and Scopus were searched up to February 2022. The inclusion criteria were all studies testing antibiotic resistance of probiotic Lactobacillus strains present in human food supplementation and all human/animal model studies in which transferring antibiotic-resistant genes from Lactobacillus strains to another bacterium were investigated. Findings/Results : Phenotypic and genotypic characterization of Lactobacillus probiotics showed that the most antibiotic resistance was against protein synthesis inhibitors (fourteen studies, 87.5%) and cell wall synthesis inhibitors (ten studies, 62.5%). Nine of these studies reported the transfer of antibiotic resistance from Lactobacillus probiotic as donor species to ‎pathogenic bacteria and mostly used in vitro methods for resistance gene transfer. Conclusion and implications: The transferability of resistance genes such as tet and erm in Lactobacillus increases the risk of spreading antibiotic resistance. Further studies need to be conducted to evaluate the potential spread of antibiotic resistance traits via probiotics, especially in elderly people and newborns.
کلیدواژه‌های انگلیسی مقاله Antibiotic resistance,Lactobacillus probiotic, Probiotic safety,Systematic review.
نویسندگان مقاله | Ali Shahali
Department of Clinical Pharmacy and Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.


| Rasool Soltani
Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.


| Vajihe Akbari


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/2205
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Review Article
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