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Iranian Journal of Medical Sciences، جلد ۴۸، شماره ۵، صفحات ۴۶۵-۴۷۳
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Lipid Profile as a Predictive Marker for Organ Dysfunction after Thoracoabdominal Surgery: A Cross-sectional Study |
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| چکیده انگلیسی مقاله |
Background: Plasma total cholesterol is considered a negative acute phase reactant. In various pathological conditions, such as trauma, sepsis, burns, and liver dysfunction, as well as post-surgery, serum cholesterol level decreases. This study aimed to investigate the role of lipid profiles in determining the probability of organ dysfunction after surgery.Methods: This cross-sectional study included patients who underwent thoracoabdominal surgery and were admitted to the intensive care unit of Imam Reza Hospital in Tabriz, Iran, between October 2016 and September 2018. During the first two days of admission, blood samples were taken, and serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), Low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and albumin were measured. The relation between the changes in these laboratory markers and six organ functions including cardiovascular, respiratory, renal, central nervous system, hepatic, and hematologic, length of stay in the hospital and intensive care unit, mechanical ventilation duration, and vasopressor use were investigated. The independent t test was used to compare continuous variables. The association between different variables and organ dysfunction and mortality was evaluated by using logistic regression.Results: The serum TC increased the risk of mortality (OR=1.09, 95%CI=1.06-1.11, P< 0.001), renal dysfunction (OR=1.09, 95%CI=1.06-1.12; P< 0.001), liver dysfunction (OR=1.07, 95%CI=1.03-1.10; P< 0.001), respiratory dysfunction (OR=1.08, 95%CI=1.05-1.13; P< 0.001). Moreover, LDL, HDL, and TG were found to be inversely related to mortality, organ dysfunction, length of stay in the hospital and intensive care unit, mechanical ventilation duration, and vasopressor use. Conclusion: TC could be considered a risk factor for mortality, organ dysfunction, and clinical outcomes. On the other hand, LDL, HDL, and TG played a protective role in the patients’ mortality, organ dysfunction, and clinical outcomes. |
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| کلیدواژههای انگلیسی مقاله |
Multiple organ failure, Cholesterol, Intensive care units, Mortality |
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| نویسندگان مقاله |
Sarvin Sanaie |
Research Center for Integrative Medicine in Aging, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
Sanam Dolati |
Physical Medicine and Rehabilitation Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
Majid Montazer |
Department of Cardiothoracic Surgeries, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Sarina Ranjbari |
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
Arezoo Fathalizadeh |
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
Kamran Shadvar |
Department of Anesthesiology and Critical Care Medicine, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Elnaz Faramarzi |
Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Ata Mahmoodpoor |
Research Center for Integrative Medicine in Aging, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
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| نشانی اینترنتی |
https://ijms.sums.ac.ir/article_49142_9e8a8091229cb8037b6a288686ef6851.pdf |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
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