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Iranian Journal of Microbiology، جلد ۱۵، شماره ۴، صفحات ۵۳۳-۵۴۰
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عنوان انگلیسی Cell wall disruption, membrane damage, and decrease in the expression of Yrp1 virulence factor in Yersinia ruckeri by propolis ethanol extract
چکیده انگلیسی مقاله Background and Objectives: Instead of antibiotics, propolis is a promising alternative for treating bacterial diseases. The aim of this study was to evaluate the effect of propolis ethanol extract (PEE) on Yersinia ruckeri (Y. ruckeri), a fish pathogen, by examining its impact on the cell wall, cytoplasmic membrane, and gene expression. Materials and Methods: The effect of propolis on the bacterial cell wall, membrane, and DNA using scanning electron microscopy (SEM) was investigated. Its effect on the NAD+/NADH ratio, reactive oxygen species (ROS) production, as well as the expression of a virulence factor (yrp1) was also determined. Results: It was demonstrated that PEE has multiple antibacterial mechanisms against Y. ruckeri involving cell wall damage, membrane lysis, and a decrease in gene expression. Conclusion: The obtained results indicated that the mode of propolis action against Y. ruckeri is both structural and functional, while others showed propolis only could inactivate bacteria in a structural way.
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نویسندگان مقاله | Fardin Sheydai
Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran


| Amir Tukmechi
Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/4179
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