|
|
Iranian Journal of Pharmaceutical Research، جلد ۱۳، شماره ۱، صفحات ۱۹۹-۲۰۶
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Embryo Toxic Effects of Depleted Uranium on the Morphology of the Mouse Fetus |
|
| چکیده انگلیسی مقاله |
AbstractAlthough the biokinetics, metabolism, and chemical toxicity of uranium are well known, until recently little attention was paid to the potential toxic effects of uranium on reproduction and development in mammals. In recent years, it has been shown that uranium is a developmental toxicant when given orally or subcutaneously (SC) to mice. Decreased fertility, embryo/fetal toxicity including teratogenicity, and reduced growth of the offspring have been observed following uranium exposure at different gestation periods. For investigating the effects of DU on pregnant animals, three groups (control, sham and test) of NMRI mice were chosen. In test group 4mg/kg of DU were administered intraperitonealy at 11 day of gestation, in sham group only normal saline injected to interior peritoneum as indicated in the test group and in Control group which was considered as the comparison base line of our research, no injection was made. Caesarean sections were performed at 15 day of the gestation; and their placentas were examined externally. Base on our results DU caused significant external anomalies, and caused a significant decrease (p< 0.05) in the weight and diameter of placentas, the number of the embryos, their body weight and crown-rump length of fetuses. |
|
| کلیدواژه‌های انگلیسی مقاله |
|
|
| نویسندگان مقاله |
نینا میردریکوند | nina mirderikvand
faculty of pharmacy, shahid beheshti university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
بهارک محمدزاده اصل | baharak mohammadzadeh asl
faculty of pharmacy, shahid beheshti university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
پروانه ناصرزاده | parvaneh naserzadeh
department of pharmacology and toxicology, faculty of pharmacy, shahid beheshti university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
فاطمه شکی | fatemeh shaki
school of pharmacy, mazandaran university of medical sciences, sari, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
محمد شکرزاده | mohammad shokrzadeh
school of pharmacy, mazandaran university of medical sciences, sari, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
جلال پوراحمد | jalal pourahmad
-
|
|
| نشانی اینترنتی |
http://ijpr.sbmu.ac.ir/article_1449.html |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/127/article-127-277615.pdf |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
Research article |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|