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Iranian Journal of Pharmaceutical Research، جلد ۱۴، شماره ۱، صفحات ۵۹-۶۵
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Design, Synthesis and Cytotoxicity Evaluationof New 1,2-diaryl-4, 5, 6, 7-Tetrahydro-1H-benzo[d] Imidazolesas Tubulin Inhibitors |
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| چکیده انگلیسی مقاله |
A new series of 1,2-diaryl-4,5,6,7-tetrahydro-1H-benzo[d]imidazoles, possessing trimethoxy phenyl pharmacophore, were synthesized to evaluate their biological activities as tubulin inhibitors. Cytotoxic activity of the synthesized compounds 7a-f was assessed against several human cancer cell lines, including MCF-7 (breast cancer cell), HEPG2 (liver hepatocellular cells), A549 (adenocarcinomic human alveolar basal epithelial cells), T47D (Human ductal breast epithelial tumor cell line) and fibroblast. َAccording to our results, HEPG2 seems to be the most sensitive, while MCF7 was the most resistant cell line to the compounds. All the compounds expect 7b, possessed satisfactory activity against HEPG2 with mean IC50 values raging from 15.60 to 43.81 µM. Docking simulation was performed to position these compounds into colchicine binding site to determine the probable binding model, which suggested the possible inhibition mechanism. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
مرضیه امیرمستوفیان | marzieh amirmostofian
1department of medicinal chemistry, school of pharmacy, shahid beheshti university of medical sciences, tehran iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
فرزاد کبارفرد | farzad kobarfard
department of medicinal chemistry, school of pharmacy, shahid beheshti university of medical sciences, tehran iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
حامد reyhanfard | hamed reyhanfard
department of medicinal chemistry, school of pharmacy, shahid beheshti university of medical sciences, tehran iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
ویدا مشایخی | vida mashayekhi
department of pharmaceutical biotechnology, school of pharmacy, zanjan university of medical sciences, zanjan iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی زنجان (Zanjan university of medical sciences)
افشین زرقی | afshin zarghi
shahid beheshti univ. med. sci.
سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)
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| نشانی اینترنتی |
http://ijpr.sbmu.ac.ir/article_1627.html |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/127/article-127-277417.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Research article |
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