Iranian Journal of Pharmaceutical Research، جلد ۱۴، شماره ۲، صفحات ۴۶۵-۴۷۱
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عنوان انگلیسی Voltammetric Behavior and Determination of Trace Amounts of Omeprazole Using an Edge-plane Pyrolytic Graphite Electrode
چکیده انگلیسی مقاله The voltammetric performance of edge-plane pyrolytic graphite (EPG) electrode via adsorptive stripping voltammetry was investigated for study of the electrochemical behavior of omeprazole (OMZ) in aqueous solution. The results revealed that the oxidation of OMZ is an irreversible pH-dependent process that proceeds with the transfer of one electron and one proton in an adsorption-controlled mechanism. The determination conditions, such as the pH values of the supporting electrolyte, accumulation time and scan rate were optimized. Simplicity, high reproducibility and low detection limit (3 nM) of the electrode response as well as wide linear range (0.01 to 4.0 µM) can be stated as significant features of this electrode. The EPG electrode was successfully applied for the determination of OMZ in pharmaceutical formulations and satisfactory results were obtained.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله سعید شاهرخیان | saeed shahrokhian
department of chemistry, sharif university of technology, tehran 11155-9516, iran, institute for nanoscience and technology, sharif university of technology, tehran, iran

سازمان اصلی تایید شده: دانشگاه صنعتی شریف (Sharif university of technology)

معصومه قلخانی | masoumeh ghalkhani
department of chemistry, sharif university of technology, tehran 11155-9516, iran, department of chemistry, faculty of science, shahid rajaee teacher training university, lavizan, tehran, iran

سازمان اصلی تایید شده: دانشگاه تربیت دبیر شهید رجایی (Shahid rajaee teacher training university)

مریم بیات | maryam bayat
department of chemistry, sharif university of technology, tehran 11155-9516, iran

سازمان اصلی تایید شده: دانشگاه صنعتی شریف (Sharif university of technology)

فاطمه قربانی bidkorbeh | fatemeh ghorbani bidkorbeh
department of pharmaceutics, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

نشانی اینترنتی http://ijpr.sbmu.ac.ir/article_1638.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/127/article-127-277372.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Research article
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