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Iranian Journal of Pharmaceutical Research، جلد ۱۴، شماره ۲، صفحات ۴۲۵-۴۳۳
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Cyclodextrine Screening for the Chiral Separation of Carvedilol by Capillary Electrophoresis |
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| چکیده انگلیسی مقاله |
Carvedilol is administered as a racemic mixture of the R(+)- and S(-)-enantiomers, although it was demonstrated that the two enantiomers exhibit different pharmacological effects and stereoselective pharmacokinetics. The aim of this study was the evaluation of several native and derivatized cyclodextrines as chiral selectors for the separation of carvedilol enantiomers. Stereoselective interactions were observed with four cyclodextrines (β-CD, hydroxypropyl-β-CD, randomly methylated β-CD and sulfobuthyl ether- β-CD). The effects of CD concentration, pH value and composition of the background electrolyte, capillary temperature, running voltage and injection parameters have been investigated. The method was validated for precision of peak-area response, linearity range and limits of detection and quantification. An efficient stereoselective capillary zone electrophoretic method was developed for the determination of carvedilol enantiomers using a simple 25 mM phosphate buffer at a pH = 2.5 and 10 mM β-CD as chiral selector, resulting in baseline separation of the two enantiomers with sharp peaks and relatively short analysis time. Highly satisfactory results were obtained from the analysis of carvedilol from tablets, indicating that the method is suitable for routine analysis of carvedilol in pharmaceutical products. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
جبراییل hancu | gabriel hancu
university of medicine and pharmacy targu mures, faculty of pharmacy, department of pharmaceutical chemistry
anca cârje | anca cârje
university of medicine and pharmacy targu mures, faculty of pharmacy, department of analytical chemistry
ileana iuga | ileana iuga
university of medicine and pharmacy, faculty of pharmacy, department of pharmaceutical chemistry
ibolya fülöp | ibolya fülöp
university of medicine and pharmacy targu mures, faculty of pharmacy, department of toxicology and biofarmacy
zoltán szabó | zoltán szabó
university of medicine and pharmacy targu mures, faculty of pharmacy, department of pharmaceutical chemistry
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| نشانی اینترنتی |
http://ijpr.sbmu.ac.ir/article_1657.html |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/127/article-127-277368.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Research article |
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