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Iranian Journal of Pharmaceutical Research، جلد ۱۴، شماره ۲، صفحات ۴۰۷-۴۱۵
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Galactosylated Albumin Nanoparticles of Simvastatin |
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| چکیده انگلیسی مقاله |
The present study , was an attempt to develop galactosylated albumin nanoparticles of Simvastatin for treatment of hypercholesterolemia. By developing the galactosylated nanoparticulated delivery the required action of drug at the target site at liver can be provided. The advantage of targeting helps to reduce the systemic side effects which may be occur due to the distribution of the drug to the other organs and thus helps in maintaining the required concentration of drug at the desired site.The galacotsylated albumin nanoparticles were prepared for the selective delivery of an, Simvastatin to the 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) the rate limiting enzyme in the pathway of cholesterol biosynthesis which is particularly presents on liver. The albumin nanoparticles (NPs) were prepared by using desolvation method and efficiently conjugated with galactose. Various parameters such as particle size, zeta potential, percentage entrapment efficiency and drug loading efficiency, percentage yield, in vitro drug release were determined. The size of nanoparticles (both plain and coated NPs) was found to be 200 and 250 nm. The zeta potential of plain nanoparticles was found to be -3.61 and that of galactose coated nanoparticles was found to be 64.1.The maximum drug content was found in between 79.98% to 79.8 % respectively in plain, and galactose coated nanoparticles while the maximum entrapment efficiency was found to be 70.10% and 71.03% in plain and coated nanoparticles. It was also found that coating of nanoparticles increases the size of nanoparticles. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
کومار ganesh | kumar ganesh
division of pharmaceutical sciences, sri guru ram rai institute of technology and sciences, patel nagar, dehradun.
dhyani آرچانا | dhyani archana
division of pharmaceutical sciences, sri guru ram rai institute of technology and sciences, patel nagar, dehradun.
kothiyal preeti | kothiyal preeti
division of pharmaceutical sciences, sri guru ram rai institute of technology and sciences, patel nagar, dehradun.
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| نشانی اینترنتی |
http://ijpr.sbmu.ac.ir/article_1704.html |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/127/article-127-277366.pdf |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Research article |
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