| چکیده انگلیسی مقاله |
A series of hydroxysemicarbazone derivatives of substituted diaryl ketones and acetophenones were synthesized and their structures were confirmed by analytical and spectroscopic methods including elemental analysis, infrared and nuclear magnetic resonance spectroscopy. The derivatives were prepared by a condensation reaction between N-hydroxysemicarbazide and substituted diaryl ketones or acetophenones leading to the desired hydroxysemicarbazones with excellent purity. The synthesized hydrazones were then evaluated for their inhibitory activity against bacterial strains including S. aureus, E. Coli, P. aeruginosa, K. pneumonia and M. luteus. Among the tested derivatives, compounds 2, 6 and 7 exhibited the highest bioactivity. Analysis of the activity data suggests that hydrophilicity is an important factor for the bioactivity of compounds 2 and 6 and also their selectivity over the gram-negative bacteria. |
| نویسندگان مقاله |
الهام حریری | elham hariri
department of medicinal chemistry, school of pharmacy, phytochemistry research center, shahid beheshti university of medical sciences, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
آرش محبوبی | arash mahboubi
department of pharmaceutics, school of pharmacy, shahid beheshti university of medical sciences, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
پریسا رحمانی | parisa rahmani
department of pharmaceutics, school of pharmacy, shahid beheshti university of medical sciences, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
کمال الدین حاج محمد ابراهیم تهرانی | kamaleddin haj mohammad ebrahim tehrani
department of medicinal chemistry, school of pharmacy, phytochemistry research center, shahid beheshti university of medical sciences, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
محمد باباییان | mohammad babaeian
department of pharmaceutics, school of pharmacy, shahid beheshti university of medical sciences, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
ویدا مشایخی | vida mashayekhi
department of medicinal chemistry, school of pharmacy, phytochemistry research center, shahid beheshti university of medical sciences, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
فرزاد کبارفرد | farzad kobarfard
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