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Nanomedicine Journal، جلد ۱۰، شماره ۳، صفحات ۱۶۳-۱۷۰
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عنوان انگلیسی Recent advances in nanocarriers containing Bromelain: In vitro and in vivo studies
چکیده انگلیسی مقاله Medicinal products of plant origin have long been considered the most affordable and accessible sources to treat different health problems. Bromelain (Br) is a mixture of enzymes derived from pineapple (Ananas comosus L.) with a wide field of applications including medicine, health, food, and cosmetics. Br has various therapeutic effects, such as antimicrobial, antioxidant, anticancer, wound healing, burn treatment, pain relief, anti-inflammatory, inhibition of platelet aggregation, and fibrinolytic activity. On the other hand, most proteins are susceptible to denaturation and structural changes that may reduce their activities. Encapsulation of drug molecules into nanoparticles (NPs) could increase their stability, bioavailability, and overcome other challenges in drug delivery and therapy. This review aimed to highlight various Br nano-formulations approaches, toward the improvement of Br therapeutic efficiency. 
کلیدواژه‌های انگلیسی مقاله Bromelain, Nanoparticles, Pineapple, Stability, Therapeutic application
نویسندگان مقاله | Ashkan Safavinia
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| Sina Dehestani
Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA


| Zahra Salmasi
Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran|Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran


| Fatemeh Kalalinia
Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran|Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| Leila Etemad
Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran|Department of Drug and Food Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| Maryam Hashemi
Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran|Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی https://nmj.mums.ac.ir/article_21288.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Review Paper
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