|
|
Journal of Sciences Islamic Republic of Iran، جلد ۱۳، شماره ۱، صفحات ۰-۰
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE GENE (iNOS) STIMULATED BY HYDROGEN PEROXIDE IN HUMAN ENDOTHELIAL CELLS |
|
| چکیده انگلیسی مقاله |
Inducible nitric oxide synthase (iNOS) gene expresses a calcium calmudolin-independent enzyme which can catalyse NO production from L-arginine. The induction of iNOS activity has been demonstrated in a wide variety of cell types under stimulation with cytokines and lipopoly saccharide (LPS). Previous studies indicated that all nitric oxide synthases (NOS) activated in human umbilical vein endothelial cells (HUVEC) were calcium dependent. In this work we indicate that endothelial cells can express iNOS mRNA under stimulation by cytokines, LPS and H2O2. We also found that iNOS mRNA expression has increased by augmentation of H2O2 concentration and its expression depends on increasing in time. Therefore we conclude that two isoforms of NOS are expressed in the HUVEC and induction of iNOS enzyme by H2O2 and NO production in endothelial cells may represent a novel cellular defence mechanism against oxidative stress and infections. |
|
| کلیدواژه‌های انگلیسی مقاله |
|
|
| نویسندگان مقاله |
|
|
| نشانی اینترنتی |
http://jsciences.ut.ac.ir/article_31748_6fa6491075c0e28c24f902bf72b1fde2.pdf |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/513/article-513-275671.pdf |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
|
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|