Iranian Journal of Basic Medical Sciences، جلد ۱۹، شماره ۱۲، صفحات ۱۳۶۸-۱۳۷۵
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Carthamus tinctorius L. ameliorates brain injury followed by cerebral ischemia-reperfusion in rats by antioxidative and anti-inflammatory mechanisms
چکیده انگلیسی مقاله Objective(s): Carthamus tinctorius L. (CT) or saffloweris widely used in traditional Chinese medicine. This study investigated the effects of CT extract (CTE) on ischemia–reperfusion (I/R) brain injury and elucidated the underlying mechanism. Materials and Methods: The I/R model was conducted by occlusion of both common carotid arteries and right middle cerebral artery for 90 min followed by 24 hr reperfusion in Sprague-Dawley rats. CTE (0.2-0.6 g/kg) was administered intraperitoneally before and during ischemia, and during reperfusion period. The cerebral infarction area, neurological deficit scores, free radicals (lucigenin chemiluminescence counts) and pro-inflammatory cytokines expression were measured. Results: Pretreatment and treatment with CTE significantly reduced the cerebral infarction area and neurological deficits. CTE (0.4 g/kg) also reduced blood levels of free radicals and expression of tumor necrosis factor-α and interleukin-1β in the cerebral infarction area. Conclusion: The reduction in I/R cerebral infarction caused by CTE is possibly associated with its antioxidation and anti-inflammatory properties.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله pin kuei fu | pin kuei fu
department of critical care medicine, taichung veterans general hospital, taichung, 40705, taiwan


طایی لنگ پانته | tai long pan
school of traditional chinese medicine, chang gung university, taoyuan, taiwan|research center for industry of human ecology, chang gung university of science and technology, taoyuan, taiwan


chi yu یانگ | chi yu yang
animal technology laboratory, agriculture technology research institute, miaoli, taiwan


kee چینگ راستین jeng | kee ching jeng
department of medical research, tungs’ taichung metroharbor hospital, taichung 43503, taiwan


nou ying تنگ | nou ying tang
school of chinese medicine, college of chinese medicine, china medical university, taichung, taiwan


چینگ راستین liang hsieh | ching liang hsieh
research center for chinese medicine amp;amp; acupuncture, china medical university, taichung, taiwan|graduate institute of integrated medicine, college of chinese medicine, china medical university, taichung, taiwan|department of chinese medicine, china medical university hospital, taichung, taiwan
نشانی اینترنتی http://ijbms.mums.ac.ir/article_7925.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-274595.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Short Communication
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