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Iranian Journal of Microbiology، جلد ۸، شماره ۵، صفحات ۳۳۸-۳۴۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Molecular typing methods used in studies of Mycobacterium tuberculosis in Iran: a systematic review
چکیده انگلیسی مقاله Background and Objectives: Molecular typing methods are important and useful tools to assess the transmission, diversity of strains and differentiation between new infections and relapses which can effectively help in controlling infections. The aim of this study was to evaluate the molecular typing methods which have been used in Iran. By evaluating the results and discriminatory power of each method, we can assign appropriate weight to each technique and ultimately offer a common strategy for future epidemiological studies. Method: We searched several databases to identify studies addressing Mycobacterium tuberculosis molecular epidemiology in Iran. Hunter-Gaston discrimination index (HGDI) was used to evaluate the discriminatory power in each method. Relevant articles were selected and analyzed; HGDI index was calculated for each technique. Results: The most common genotyping methods used in the articles were RFLP, MIRU-VNTR, spoligotyping, PFGE and RAPD-PCR. The most frequently techniques were IS 6110 -RFLP, MIRU-VNTR and spoligotyping alone or in combination. The highest discrimination power (average HGDI: 0.9916) was obtained by RFLP followed by MIRU-VNTR (average HGDI: 0.9638) and spoligotyping (average HGDI: 0.9041) respectively. Conclusion: Combination of MIRU-VNTR with spoligotyping can be recommended for large-scale genotyping in Iran. It seems appropriate to consider spoligotyping as the first technique for screening followed by other techniques with higher discrimination power such as MIRU-VNTR or IS 6110 -RFLP. Keywords: Mycobacterium tuberculosis, molecular epidemiology, genotyping, HGDI, RFLP, MIRU-VNTR, spoligotyping
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله حسن روان سالار | hassan ravansalar
antimicrobial resistance research center, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

کیوان تدین | keyvan tadayon


کیارش قزوینی | kiarash ghazvini
antimicrobial resistance research center, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://ijm.tums.ac.ir/index.php/ijm/article/view/930
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/91/article-91-269909.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Articles
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