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Avicenna Journal of Medical Biotechnology، جلد ۱۵، شماره ۲، صفحات ۱۱۸-۱۲۳
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Human T2R38 Bitter Taste Receptor Expression and COVID-19: From Immunity to Prognosis |
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| چکیده انگلیسی مقاله |
Background: Bitter taste-sensing type 2 receptor (T2Rs or TAS2Rs) found on ciliated epithelial cells and solitary chemosensory cells have a role in respiratory tract immunity. T2Rs have shown protection against SARS-CoV-2 by enhancing the innate immune response. The purpose of this review is to outline the current sphere of knowledge regarding this association. Methods: A narrative review of the literature was done by searching (T2R38 OR bitter taste receptor) AND (COVID-19 OR SARS-CoV-2) keywords in PubMed and google scholar. Results: T2R38, an isoform of T2Rs encoded by the TAS2R38 gene, may have a potential association between phenotypic expression of T2R38 and prognosis of COVID-19. Current studies suggest that due to different genotypes and widespread distributions of T2Rs within the respiratory tract and their role in innate immunity, treatment protocols for COVID-19 and other respiratory diseases may change accordingly. Based on the phenotypic expression of T2R38, it varies in innate immunity and host response to respiratory infection, systemic symptoms and hospitalization. Conclusion: This review reveals that patients' innate immune response to SARS-COV-2 could be influenced by T2R38 receptor allelic variations. |
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| کلیدواژه‌های انگلیسی مقاله |
Bitter taste receptors (T2Rs), Coronavirus disease, COVID-19, Infection, T2R38 |
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| نویسندگان مقاله |
| Lakshmi Deepak Bethineedi
Andhra Medical College, Visakhapatnam, Andhra Pradesh, India
| Hediyeh Baghsheikhi
USERN Office, Shahid Beheshti University of Medical Sciences, Tehran, Iran
| Afsaneh Soltani
USERN Office, Shahid Beheshti University of Medical Sciences, Tehran, Iran
| Zahedeh Mafi
USERN Office, Shahid Beheshti University of Medical Sciences, Tehran, Iran
| Noosha Samieefar
USERN Office, Shahid Beheshti University of Medical Sciences, Tehran, Iran
| Shaikh Sanjid Seraj
Walsall Healthcare NHS Trust, Walsall Manor Hospital, Walsall, United Kingdom
| Mohammad Amin Khazeei Tabari
USERN Office, Mazandaran University of Medical Sciences, Sari, Iran
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| نشانی اینترنتی |
https://www.ajmb.org/En/Article.aspx?id=60538 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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