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Journal of Kerman University of Medical Sciences، جلد ۲۹، شماره ۲، صفحات ۱۲۳-۱۳۳
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عنوان انگلیسی Evaluation of Levofloxacin-containing Regime in Comparison with Clarithromycin-containing Regime in Eradicating Helicobacter pylori Infection in Kerman
چکیده انگلیسی مقاله Background: Helicobacter pylori (H.pylori) is the main known cause of gastritis, gastroduodenal ulcer disease, and gastric cancer. Eradication of H.pylori can be an effective method of treatment for peptic ulcer disease and mucosa‐associated lymphoid tissue lymphoma. This study aimed to compare the effectiveness of levofloxacin versus clarithromycin in the eradication of H.pylori.Methods: This randomized clinical trial was conducted on 170 cases with H.pylori infection in Kerman. The participants were randomly allocated to two groups. As the first line therapy, ‘A’ group was treated twice a day with clarithromycin (500mg), pantoprazole (40mg) and amoxicillin (1gr) for 14 days and ‘B’ group was treated twice a day with levofloxacin (250mg), pantoprazole (40mg) and amoxicillin (1gr) for 14 days. Stool H.pylori antigen test was performed one month after the end of treatment. To analyze the data, descriptive and analytical methods and SPSS software version 22 were used.Results: The study cases were comprised of 170 individuals (52.35%female). The mean age of patients in ‘A’ and ‘B’ groups was 42±11.88 and 41±13.75 years, respectively. H.pylori eradication was successful in 61.1% of ‘A’ group and 92.9% of ‘B’ group showing a significant difference (P=0.037). Drug complications were reported in 7.1% of ‘A’ group and 4.7% of ‘B’ group which showed no significant difference between the two groups (P=0.772). The most common drug complication in both groups was abdominal pain (2.3%).Conclusion: The results of this study indicated that levofloxacin-containing regimen was more effective in eradicating H.pylori than the standard clarithromycin triple therapy.
کلیدواژه‌های انگلیسی مقاله Eradication, Helicobacter pylori, Antibiotic, Digestion
نویسندگان مقاله Bizhan Ahmadi |
Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

Masoud Hajmohammadi |
Department of Internal Medicine, School of Medicine, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran

Ali Saeed Pour |
Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

Motahareh Zaherara |
Department of Medical Basic Sciences, School of Medicine, Bam University of Medical Sciences, Bam, Iran

Sara Shafieepour |
1. Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

Hoshang Ghazizadeh Ahsaei |
Sepehr Laboratory, Kerman, Iran

نشانی اینترنتی https://jkmu.kmu.ac.ir/article_91889_828bc3cd61e13ad519f60f460e92108a.pdf
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