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Journal of Kerman University of Medical Sciences، جلد ۲۹، شماره ۲، صفحات ۱۱۲-۱۲۲
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عنوان انگلیسی Beneficial Effects of Dual Frequency Sonodynamic Therapy and Hematoporphyrin Mesoporous Silica Nanoparticles in the Treatment of Mice Breast Adenocarcinoma
چکیده انگلیسی مقاله Background: Sonodynamic therapy (SDT) may be a new hopeful non-invasive method for cancer treatment, which incorporates a combination of low-intensity ultrasound and a sonosensitive chemical. The goal of this study was to evaluate the effect of dual-frequency sonication (1 and 3 MHz) and injected Hematoporphyrin encapsulated in mesoporous silica nanoparticles (HP-MSNs) as a sensitizer in the treatment of mice grafted with breast adenocarcinoma.Methods: In this research, one hundred and thirty-two female mice with grafted breast adenocarcinoma were separated into 22 groups including control, sham, 4 groups of sonication 1 or 3 MHz (1 and 2 W/cm2), and 16 groups of SDT with Hematoporphyrin (HP) and HP-MSNs (2.5 and 5 mg/kg). The tumor growth factors and tumor grading were used to assess the treatment management.Results: The results indicate that dual-frequency sonication has a delayed effect on tumor growth. The required time of T5 to the initial volume in all groups of SDT with HP (5 mg/kg) was greater than that in the control group (P< 0.05). It was observed that SDT with an injection of HP-MSNs was effective in delaying tumor growth and the time of T2 and T5 was higher than that of other groups (P< 0.05). This group had Grade II (intermediate), while others had Grade III (high) malignancy in the histological study of mice breast adenocarcinoma. Conclusion: Our results reveal that dual-frequency SDT therapy with HP-MSN has a delaying tumor growth effect on mice breast adenocarcinoma. Hence, the expansion of minimally invasive methods such as SDT is necessary.
کلیدواژه‌های انگلیسی مقاله breast cancer, Adenocarcinoma, Dual frequency, Sonodynamic therapy, Hematoporphyrin, Mesoporous silica nanoparticle
نویسندگان مقاله Monireh Hoseinzadeh |
Department of Medical Physics, Semnan University of Medical Sciences, Semnan, Iran

Majid Jadidi |
Department of Medical Physics, Semnan University of Medical Sciences, Semnan, Iran

Hadi Hasanzadeh |
Department of Medical Physics, Semnan University of Medical Sciences, Semnan, Iran

Tahereh Khani |
Department of Medical Physics, Semnan University of Medical Sciences, Semnan, Iran

Shoka Shahryari |
Department of Medical Physics, Semnan University of Medical Sciences, Semnan, Iran

Shima Saeedi |
Department of Medical Physics, Semnan University of Medical Sciences, Semnan, Iran

نشانی اینترنتی https://jkmu.kmu.ac.ir/article_91888_e2b9a60c40adf02fb8b0e854284a4e48.pdf
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