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Journal of Kerman University of Medical Sciences، جلد ۲۹، شماره ۶، صفحات ۵۶۸-۵۷۶
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عنوان انگلیسی Biological Functions of Nitric Oxide in the Brain and Brain Stem
چکیده انگلیسی مقاله Nitric oxide (NO) is a small biological arbitrator and signaling molecule that has numerous significant biological roles in our body. Most of the neurons produce NO by neuronal nitric oxide synthase (nNOS). NO has been involved in the regulation of neurogenesis, synaptic plasticity, learning, and memory. Also, it contributes to the regulation of circulation and synapses, cerebral map formation, and neuropeptides. In the current review, we focused on previous research that has demonstrated structural aspects, subcellular localization, and some factors that adjust nNOS function. Furthermore, we have characterized the effect of nNOS in the brain in some physiological situations, particularly long-term potentiation and depression (LTP and LTD) and neural plasticity during development . Moreover, the effect of NO on neuropeptidergic neurons, including orexin, in reward systems was reviewed. Also, this study has focused on the NO involvement in brain circulation, the excitability of neurons, and the homeostatic balance of excitatory and inhibitory signaling in the brain.
کلیدواژه‌های انگلیسی مقاله Nervous system, nitric oxide, brain, Brain stem
نویسندگان مقاله Zahra Rezaei |
Department of Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran

Sohrab Hajizadeh |
Department of Physiology, Medical School, Tarbiat Modares University, Tehran, Iran

Zahra Piri |
Department of Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran

نشانی اینترنتی https://jkmu.kmu.ac.ir/article_92098_a018881f169222335a1f7dfbe9e80fbc.pdf
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