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Iranian Journal of Microbiology، جلد ۱۵، شماره ۱، صفحات ۱۵۵-۱۶۲
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عنوان انگلیسی Phylogenetic characterization of rhinovirus and adenovirus in hospitalized children aged ≤ 18 years with severe acute respiratory infection in Iran
چکیده انگلیسی مقاله Background and Objectives: Human rhinoviruses (HRVs) and human adenoviruses (HAdVs) are among the most prevalent viruses in hospitalized patients with severe acute respiratory infection (SARI). This study aimed to evaluate the molecular characterization of HRV and HAdV in hospitalized patients with SARI, who aged ≤ 18 years in Tehran, Iran. Materials and Methods: To detect these two viruses, a conventional nested RT-PCR (Reverse transcription-polymerase chain reaction) assay was performed on 264 throat swabs collected from December 2018 to March 2019. The epidemiological data were analyzed and phylogenetic trees were constructed. Results: Of 264 cases with SARI, 36 (13.6%) and 28 (10.6%) were positive for HAdV and HRV respectively. Of 21 HRV sequenced samples, HRV-A (42.9%), HRV-B (9.5%) and HRV-C (47.6%) and of 36 HAdV sequenced samples, HAdV-C6 (38.9%), HAdV-B7 (22.2%), HAdV-B3 (11.1%), HAdV-B16 (5.6%), HAdV-C5 (13.9%), HAdV-C57 (5.6%), HAdV-E4 (2.8%); were detected in children with SARI. Some viral genotypes appeared to cause more severe disease, which may lead to hospitalization. Conclusion: Large-scale studies are recommended to investigate the epidemiology and molecular characterizations through surveillance networks to provide useful information on etiology, seasonality, and demographic associations in patients with SARI.
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نویسندگان مقاله | Simin Abbasi
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Nazanin Zahra Shafiei-Jandaghi
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Azadeh Shadab
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Seyed Abbas Hassani
Department of Pediatric Intensive Care Unit, Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran


| Abbas Rahimi Foroushani
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Nazanin Hosseinkhan
Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran


| Fahimeh Aghamir
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Talat Mokhtari-Azad
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Jila Yavarian
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Research Center for Antibiotic Stewardship and Antimicrobial Resistance, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/3813
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