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Iranian Journal of Basic Medical Sciences، جلد ۲۵، شماره ۱۰، صفحات ۱۲۴۳-۱۲۵۰

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عنوان انگلیسی MiR-574-5p promotes cell proliferation by negatively regulating small C-terminal domain phosphatase 1 in esophageal squamous cell carcinoma
چکیده انگلیسی مقاله Objective(s): Esophageal cancer is one of the most common cancers with high incidence and mortality rates, especially in China. MicroRNA (miRNA) can be used as a prognostic marker for various human cancers. This study aims to detect suitable miRNA markers for esophageal squamous cell carcinoma (ESCC). Materials and Methods: Our previous gene expression data of ESCC cells and the data from GSE43732 and GSE112840 were analyzed. The expression of miR-574-5p in ESCC patients and controls was analyzed by real-time quantitative PCR. The effect of miR-574-5p on proliferation was detected by real-time cell analysis (RTCA) and EdU proliferation assay after cell transfections. The target gene small C-terminal domain phosphatase 1 (CTDSP1) of miR-574-5p was validated by luciferase reporter assay and western blotting.Results: In the current study, the bioinformatics analysis found miR-574-5p up-regulated in ESCC. The qPCR assay of 26 ESCC and 13 adjacent/ normal tissues confirmed these results. We further demonstrated that miR-574-5p overexpression promoted cell proliferation. Then the dual-luciferase reporter assay and the rescue experiment suggested that CTDSP1 was a direct target of miR-574-5p.Conclusion: MiR-574-5p played an oncological role in ESCC by interacting and negatively regulating CTDSP1. These results provided a deeper understanding of the effect of miR-574-5p on ESCC.
کلیدواژه‌های انگلیسی مقاله Cell Proliferation, CTDSP1 protein, Esophageal squamous cell carcinoma, MiR-574-5p, Oncogene Protein v-akt

نویسندگان مقاله | Chunming Zhao
Department of Human Anatomy, Xuzhou Medical University, Xuzhou, Jiangsu, China|Jiangsu Medical Engineering Research Center of Gene Detection, Xuzhou Medical University, Xuzhou, Jiangsu, China


| Jialin Liu
Department of Forensic Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, China|Jiangsu Medical Engineering Research Center of Gene Detection, Xuzhou Medical University, Xuzhou, Jiangsu, China


| Yong Xu
Department of Forensic Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, China|Jiangsu Medical Engineering Research Center of Gene Detection, Xuzhou Medical University, Xuzhou, Jiangsu, China


| Jiamei Guo
Department of Forensic Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, China|Jiangsu Medical Engineering Research Center of Gene Detection, Xuzhou Medical University, Xuzhou, Jiangsu, China


| Liping Wang
Department of Basic Pathology, Pathology College, Qiqihar Medical University, Qiqihar, Heilongjiang, China


| Linfen Chen
Department of Forensic Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, China|Jiangsu Medical Engineering Research Center of Gene Detection, Xuzhou Medical University, Xuzhou, Jiangsu, China


| Lina Xu
NGS center, Hangzhou D.A. Medical Laboratory Co., Ltd., Hangzhou, Zhejiang, China


| Guokai Dong
Department of Forensic Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, China|Jiangsu Medical Engineering Research Center of Gene Detection, Xuzhou Medical University, Xuzhou, Jiangsu, China


| Wei Zheng
Department of Orthopedics, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China


| Zhouru Li
Department of Forensic Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, China|Jiangsu Medical Engineering Research Center of Gene Detection, Xuzhou Medical University, Xuzhou, Jiangsu, China


| Hongxing Cai
Department of Forensic Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, China|Jiangsu Medical Engineering Research Center of Gene Detection, Xuzhou Medical University, Xuzhou, Jiangsu, China


| Shanshan Li
Department of Forensic Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, China|Jiangsu Medical Engineering Research Center of Gene Detection, Xuzhou Medical University, Xuzhou, Jiangsu, China



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