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Journal of Dentistry, Shiraz University of Medical Sciences، جلد ۲۳، شماره Supplement-September-۲۰۲۲، صفحات ۳۷۷-۳۸۲
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عنوان انگلیسی Combination of Binary System with Ki67 Immunohistochemical Staining: a Reliable Grading Method for Oral Epithelial Dysplasia
چکیده انگلیسی مقاله Statement of the Problem: Oral epithelial dysplasia (OED) is a common potentially malignant lesion of oral cavity that should be managed to prevent likely malignant transformation.Purpose: Here, we present a combination of binary grading system with complementary immunohistochemical (IHC) staining for Ki67 biomarker to provide a reproducible OED grading system.Materials and Method: In this cross-sectional study, seventy out of one hundred OED specimens, which were accompanied by IHC stained microscopic slides for Ki67 antigen were evaluated by four independent oral pathologists. Both three-tier and binary grading systems based on WHO microscopic criteria were employed , blindly in a four-step method with at least two-week interval between each observation. Intra- and inter-observational reliability was assessed using Kappa statistical analysis.Results: OED diagnosis based on binary system showed significant intra-observer reliability comparing to three-tier system without biomarker. Moreover, OED diagnosis based on binary system using Ki67 biomarker showed significant inter-observer reliability comparing to diagnosis in three tier system and based on binary system without Ki67 biomarker showed significant inter-observer reliability comparing to diagnosis based on three-tier system without Ki67.Conclusion: Here, we found that application of IHC staining for Ki67 biomarker in binary system might provide a more reliable grading method for oral pathologist form different educational background.
کلیدواژه‌های انگلیسی مقاله Ki-67 antigen, Precancerous Conditions, Carcinoma in Situ
نویسندگان مقاله Negar Akafzadeh |
Postgraduate Student of Pediatric Dentistry, Department of Pediatric Dentistry, School of Dentistry, Qazvin University of Medical Sciences, Qazvin , Iran

Fereshteh Baghaei |
Retired Professor, Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

Samira Derakhshan |
Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

Monir Moradzadeh Khiavi |
Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

Mohamadjavad Kharazifard |
Researcher, Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Pouyan Aminishakib |
Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

نشانی اینترنتی https://dentjods.sums.ac.ir/article_48415_17ac21d5c5fdbfcc59ebbdbff4f009f9.pdf
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