این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Nanomedicine Journal، جلد ۹، شماره ۳، صفحات ۵۲۵-۲۶۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی In vitro cytotoxicity of Cuminum cyminum essential oil loaded SLN nanoparticle
چکیده انگلیسی مقاله Objective(s): Encapsulation of essential oils (EOs) into the nano-carrier leads to reduced EOs volatility and oxidation, as well as increased therapeutic efficiency. This study assessed the chemical composition and cytotoxic effects of cumin essential oil (CEO) and nano-encapsulation cumin essential oil (NECEO) against three cancer cell lines. Materials and Methods: Solid lipid nanoparticle (SLN) formulations were evaluated for their size, zeta potential and encapsulation efficiency (EE). Isolation of the CEO and NECEO and their chemical composition were analyzed by gas chromatography-mass spectrometry (GC/MS). Cytotoxicity of CEO and NECEO against human lung cancer (A549), human breast cancer (MCF7), and human prostate cancer (PC3) was examined using MTT assay. Results: Our findings showed that in CEO and NECEO, the major component was cuminaldehyde (24.5 and 26.0%, respectively). GC/MS analysis of NECEO chemical composition exposed 27 components in EOs accounting for 91.5 and 98.9% of CEO and NECEO, respectively. The results showed that solid lipid nanoparticle (SLN) induced the concentration of the main volatile components. Based on the characterization of SLN, the EE percent ranged from 23.00±4.1% to 96.21±5.5%. The loading capacity (LC) of NECEO ranged between 0.00±0.0 to 7.05±0.5%. Moreover, the yield of NECEO was 79.14%. Based on results, Z-average, polydispersity index, and zeta potentials of formulation were 1252±21.4 nm, 0.423±0.03, and 17±0.52, respectively. The IC50 value of NECEO (after 48 h) against MCF7, A549, and PC3 (108, 213, and 124 μg/mL, respectively) was significantly lower than CEO (231, 219, and 325 μg/mL, respectively). Conclusion: The results suggested that NECEO can be regarded as a promising nutrient source. These observations could be used as a basis for future experiments to further evaluate potential nanoparticles and other medicinal plant species.
کلیدواژه‌های انگلیسی مقاله Breast Cancer, Cuminum cyminum, Lung cancer, Prostate cancer, Solid lipid nanoparticle
نویسندگان مقاله | Masoud Tavasoli
Department of Horticultural Science, Faculty of Agriculture, Shirvan Branch, Islamic Azad University, Shirvan, Iran


| Maryam Tatari
Department of Agronomy, Faculty of Agriculture, Shirvan Branch, Islamic Azad University, Shirvan, Iran


| Maliheh Samadi Kazemi
Department of Chemistry, Faculty of Sciences, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran


| Seyedeh Faezeh Taghizadeh
Department of Horticultural Sciences, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran|Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی https://nmj.mums.ac.ir/article_20204.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده مقاله پژوهشی
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات