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Research in Pharmaceutical Sciences، جلد ۱۸، شماره ۱، صفحات ۱۶-۲۳
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عنوان انگلیسی Effects of GABAB receptor blockade on lateral habenula glutamatergic neuron activity following morphine injection in the rat: an electrophysiological study
چکیده انگلیسی مقاله Background and purpose: The lateral habenula (LHb), a key area in the regulation of the reward system, exerts a major influence on midbrain neurons. It has been shown that the gamma-aminobutyric acid (GABA)-ergic system plays the main role in morphine dependency. The role of GABA type B receptors (GABA B Rs) in the regulation of LHb neural activity in response to morphine, remains unknown. In this study, the effect of GABA B Rs blockade in response to morphine was assessed on the neuronal activity in the LHb. Experimental approach: The baseline firing rate was recorded for 15 min, then morphine (5 mg/kg; s.c) and phaclofen (0, 0.5, 1, and 2 µg/rat), a GABA B Rs’ antagonist, were microinjected into the LHb. Their effects on firing LHb neurons were investigated using an extracellular single-unit recording in male rats. Findings/Results: The results revealed that morphine decreased neuronal activity, and GABA B Rs blockade alone did not have any effect on the neuronal activity of the LHb. A low dose of the antagonist had no significant effect on neuronal firing rate, while blockade with doses of 1 and 2 µg/rat of the antagonist could significantly prevent the inhibitory effects of morphine on the LHb neuronal activity. Conclusion and implications: This result indicated that GABA B Rs have a potential modulator effect, in response to morphine in the LHb.
کلیدواژه‌های انگلیسی مقاله Extracellular single-unit recording,GABAB receptors,Lateral habenula,Morphine.
نویسندگان مقاله | Elahe Amohashemi
Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.


| Hojjatallah Alaei
Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.


| Parham Reisi


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/2164
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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