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Journal of Clinical Care and Skills، جلد ۳، شماره ۴، صفحات ۰-۰
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عنوان انگلیسی Diagnosis of coronavirus by measuring serum concentrations of IL-6 and blood ferritin
چکیده انگلیسی مقاله Aims:The purpose of this study is to explore changes of pathogenesis markers in peripheral blood of severe COVID-19 patients, which may be of value in disease monitoring. Methods: In this case-control study, we collected data of 180 subjects in two groups including 137 patients with COVID-19 (case) and 43 with non-COVID-19 (control) between March 20 and May 21, 2020, and the clinical characteristics and inflammatory markers of patients diagnosed by laboratory test.The data were analyzed by SPSS software version 20. Results: The enrolled COVID-19 patients consisted of 59.9% males and 40.1% females with the medium age of 45.96±18.49 years and there were 48.8% males and 51.2% females with the medium age of 43.23±18.30 years for non COVID-19 patients. There wasn't significant difference in the ages and sex between two groups. The frequency of positive RT-PCR test for case and control groups were 87.6% and 2.3%, respectively. A high statistically significant in means count of IL-6 and Ferritin and hematological parameters in different groups of patients with COVID-19 and non- COVID-19 were shown in this study. There was a direct positively correlated between serum level of IL-6 and Ferritin levels and hematological parameters, such as WBC, Hb and etc. with COVID-19 Conclusions: In conclusion, inflammatory markers especially IL-6 and Ferritin and hematological parameters (WBC, Lymphocytes, Neutrophils, Platelet and Hb) were positively correlated with the severity of COVID-19.Measurement of IL-6, Ferritin and hematological indices might be workable tests to monitor and evaluate the severity and prognosis of patients with COVID-19  
کلیدواژه‌های انگلیسی مقاله COVID-19, inflammatory markers, Interleukin-6, Ferritin, cytokine storm
نویسندگان مقاله | P. Yazdanpanah
Departments of Dermatology, Shahid Beheshti Hospital, Yasuj University of Medical Sciences, Yasuj, Iran.


| F. Vafaei
Departments of Pediatrician, School of Medicine and clinical research center, Emam Sajad Hospital, Yasuj University of Medical Sciences, Yasuj. Iran.


| S. Afrouz
Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
نشانی اینترنتی http://jccs.yums.ac.ir/browse.php?a_code=A-10-191-1&slc_lang=en&sid=1
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