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Iranian Journal of Microbiology، جلد ۱۴، شماره ۶، صفحات ۹۲۱-۹۲۷
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عنوان انگلیسی Molecular detection of HHV-1, HHV-2, HHV-5 and HBV in semen of fertile and infertile men by multiplex PCR method
چکیده انگلیسی مقاله Background and Objectives: A great diversity of factors including viruses such as human herpes virus 1&2 (HHV-1&2), human herpes virus 5 (HHV-5), and hepatitis B virus (HBV) play key roles in sterility and it is worth noting that male infertility accounts for nearly 50% of barrenness, globally. In this regard, we evaluated the prevalence of the aforementioned viruses in semen specimens of two distinct groups of men referred to Novin Infertility Center in Mashhad, Iran. Materials and Methods: In this cross-sectional study, 300 semen samples were collected from 150 infertile and 150 fertile men. Subsequently, genomic DNA was extracted before performing multiplex polymerase chain reaction (PCR). Eventually, the results were analyzed via SPSS Statistics V.16.0. Results: Out of 300 specimens, 183 (61.1%) were positive at least for one of the forenamed viruses; genome detection of HHV-1&2, HHV-5, and HBV were 27%, 18%, 36.66%, and 4%, respectively. Conclusion: The current study found no correlation between infertility and HBV, HHV-5, and HHV-1&2, which may have to do with factors like sample size, the geographical distribution of the viruses, and the lifestyle (sexual behavior) of the participants. These results emphasize the implementation of such studies on a broader scale to determine the exact factors involved in infertility.
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نویسندگان مقاله | Mohammad Yasaghi
Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran


| Seyyede Delafruz Hosseini
Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran


| Abdolvahab Moradi
Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran


| Mina Hassanpour
Department of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran


| Alijan Tabarraei
Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran; Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/3859
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