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Iranian Journal of Microbiology، جلد ۱۴، شماره ۵، صفحات ۷۴۰-۷۴۵
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عنوان انگلیسی Cryptococcal antigen prevalence in HIV patients from a tertiary care centre in South India
چکیده انگلیسی مقاله Background and Objectives: Cryptococcosis is an opportunistic mycosis, caused by Cryptococcus neoformans. Cryptococcal meningitis is one of the most fatal opportunistic infections associated with human immunodeficiency virus (HIV) infection. The aim of this study was to find the prevalence of cryptococcal antigenemia in people living with HIV (PLHA) and also to find the prevalence of opportunistic infections among these patients. Materials and Methods: A total of 204 non duplicate samples were collected from people with HIV aged above 18 years. Samples with CD4 count less than 300 were included in the study. Cryptococcal antigen detection was done by CrAg Lateral flow assay. Results: None of the patients in our study were positive for cryptococcal antigen. Opportunistic infections were observed in 82 (40.2%) HIV positive patients. Candidiasis, tuberculosis and Pneumocystis jiroveci pneumonia were the most common opportunistic infections. Conclusion: This is the first study from the southern state of Kerala on the prevalence of Cryptococcal antigenemia among HIV positive individuals. The study showed that routine screening for cryptococcal antigen will not be cost effective in our population. Similar to other studies, eventhough candidiasis, tuberculosis and PCP were more commonly seen among people with CD4 count < 200 cells/mm3, there was no statistically significant association.
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نویسندگان مقاله | Anitha Madhavan
Department of Microbiology, Government TD Medical College, Alappuzha, Kerala, India


| Arun Sachu
Department of Microbiology, Believers Church Medical College, Thiruvalla, Kerala, India


| Abel Samuel
Department of Community Medicine, Believers Church Medical College, Thiruvalla, Kerala, India


| Jayalakshmi Vasudevapanicker
Department of Microbiology, Government TD Medical College, Alappuzha, Kerala, India
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/3575
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