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Iranian Journal of Microbiology، جلد ۱۴، شماره ۵، صفحات ۶۸۹-۶۹۷
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عنوان انگلیسی Inhibitory effects of postbiotic consisting sonication-killed Bifidobacterium bifidum on experimental triple negative breast neoplasm in mice: a preliminary study
چکیده انگلیسی مقاله Background and Objectives: Breast cancer is the second leading cause of death and one of the most common malignancies among women in the world. The aim of this study was to investigate the preventive effects of postbiotic consisting of sonicated Bifidobacterium bifidum cells on triple negative breast cancer. Materials and Methods: Thirty-six female BALB/c mice aged 5-7 weeks were randomly divided into 3 groups (n=12): Ctrl-, healthy mice; Ctrl+, mice with breast cancer with no treatment; and Postbiotic, mice with orally gavage postbiotic before and after 4T1 cell line transplantation. Cancer progress and the effects of postbiotic were assayed by histological, immunohistochemical and gene expression quantification. Results: The histological results showed that administration postbiotic consisting of B. bifidum significantly decreased carcinogenesis in terms of tumor incidence, multiplicity and volume. The tumor progress was suppressed by oral intake of B. bifidum as showed by p53 and Ki-67 expression. Furthermore, Oral intake of postbiotic resulted in extended survival of mice and inhibited sever weigh loss. Conclusion: Pretreatment with sonication killed B. bifidum, as a postbiotic, inhibited breast cancer progress and malignancy.
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نویسندگان مقاله | Farzaneh Nazari
Department of Microbiology, Faculty of Sciences, Islamic Azad University, Arak Branch, Arak, Iran


| Parvaneh Jafari
Department of Microbiology, Faculty of Sciences, Islamic Azad University, Arak Branch, Arak, Iran


| Bizhan Nomanpour
Department of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Kambiz Varmira
Department of Medicine, Research Center of Oils and Fats, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Farshid Raissi
Department of Pathology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/3574
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