Avicenna Journal of Medical Biotechnology، جلد ۱۴، شماره ۴، صفحات ۳۱۰-۳۱۶
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عنوان انگلیسی Association between PTCH1 and RAD54B Single-Nucleotide Polymorphisms and Non-syndromic Orofacial Clefts in the Northeast Population of Iran
چکیده انگلیسی مقاله Background: Non-Syndromic Cleft Lip with or without cleft Palate (NSCL/P) is a common developmental disorder of the head and neck with a multifactorial etiology. The current study aimed to evaluate the potential association of PTCH1 (rs10512248) and RAD54B (rs12681366) polymorphisms with NSCL/P in the Northeast Iranian population. Methods: In the present study, blood samples were taken from 122 subjects with NSCL/P and 161 healthy controls. Polymerase Chain Reaction (PCR) followed by Restriction Fragment Length Polymorphism (RFLP) were used to conduct genotyping of single-nucleotide polymorphisms. Results: Although differences were observed between cases and controls in rs10512248 and rs12681366, our data did not support a significant association of these polymorphisms with NSCL/P in our population. Conclusion: Our findings suggest that polymorphisms of rs10512248 and rs12681366 may not be potential risk factors for NSCL/P in the Northeast Iranian population due to the multifactorial and multiethnicity characteristics of some genes.
کلیدواژه‌های انگلیسی مقاله Cleft lip, Cleft palate, Polymorphism, PTCH1, RAD54B
نویسندگان مقاله | Reza Morvaridi Farimani
Department of Orthodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Mohsen Azimi-Nezhad
UMR, INSERM U 1122, IGE-PCV, Interaction Géne-Environment Enpathophysiologie Cardiovasculaire, Université De Lorraine, Nancy, France


| Hamid Reza Khorram Khorshid
Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran


| Asghar Ebadifar
Dentofacial Deformities Research Center Research Institute of Dental Sciences, Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Saba Tohidkhah
Tehran University of Medical Sciences, Tehran, Iran


| Zahra Jafarian
Iranian Research Center on Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran


| Koorosh Kamali
Department of Public Health, Faculty of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran


| Zeinab Nazari
Non-Communicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran


| Reza Ebrahimzadeh-Vesal
Pardis Genetic Laboratory, Tehran, Iran
نشانی اینترنتی https://www.ajmb.org/En/Article.aspx?id=60519
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