Avicenna Journal of Medical Biotechnology، جلد ۱۴، شماره ۴، صفحات ۲۶۴-۲۶۹
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عنوان انگلیسی New Biomarkers in Early Diagnosis of Acute Kidney Injury in Children
چکیده انگلیسی مقاله Acute Kidney Injury (AKI) is a common condition with a high risk of mortality and morbidity, so, early diagnosis and management of AKI is very important in clinical practice. Despite significant progress in the management of AKI, it still carries high morbidity and mortality. BUN and serum creatinine are not very sensitive nor specific for the diagnosis of AKI because they are affected by many renal and non-renal factors that are independent of kidney injury or kidney function and change significantly only after significant kidney injury and with a substantial time delay. Detection of biomarkers of AKI made predominantly by the injured kidney tissue are essential for the early diagnosis of AKI. An ideal biomarker should be one that could be easily measured, with no interference with other biologic variables, and be able to clarify early phases of kidney damage. The most common biomarkers studied are Neutrophil Gelatinase-Associated Lipocalin (NGAL), Interleukin-18 (IL-18), Kidney Injury Molecule-1 (KIM-1), Cystatin-C, L type Fatty Acid-Binding Protein (L-FABP), N-Acetyl- β-D Glucosaminidase (NAG), netrin-1, vanin-1, and Monocyte Chemoattractant Protein-1 (MCP-1) and calprotectin.
کلیدواژه‌های انگلیسی مقاله Acute kidney injury, Biomarker, Calprotectin, Cystatin C, Interleukin-18, KIM-1, NGAL
نویسندگان مقاله | Behnaz Bazargani
Pediatric Chronic Kidney Disease Research Center, Department of Pediatric Nephrology, Children Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran


| Mastaneh Moghtaderi


نشانی اینترنتی https://www.ajmb.org/En/Article.aspx?id=60513
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