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International Journal of Reproductive BioMedicine، جلد ۲۰، شماره ۷، صفحات ۵۶۹-۵۸۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Chronic scrotal heat stress causes testicular interstitial inflammation and fibrosis: An experimental study in mice |
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| چکیده انگلیسی مقاله |
Background: Chronic heat stress is a risk factor that adversely affects the reproduction system. Inflammation and fibrosis are 2 important response processes to damaged tissues. Objective: This study investigates the association of chronic scrotal heat stress with testicular interstitial inflammation and fibrosis in mice. Materials and Methods: For all experiments, 8-10 wk old male Swiss mice (Mus musculus) (20-23 gr) were divided into 3 groups (n = 10/each). The heat stress groups were submerged in a water bath at 37°C and 40°C, while the control group was treated at 25°C. The testicular tissues were performed hematoxylin and eosin staining, picro sirius red staining, and immunohistochemistry for intercellular adhesion molecule-1, fibroblast-specific protein 1, F4/80, collagen I, and Ki-67 staining to determine the testicular interstitial inflammation and fibrosis. Results: Chronic scrotal heat stress impairs spermatogenesis and reverses testicular histological structure. Heat stress significantly induced increased interstitial cell proliferation and upregulation of intercellular adhesion molecule-1 expression in the interstitial testicular tissue. In the interstitial testicular tissue, the number of F4/80-positive macrophages and the number of fibroblast-specific protein 1-positive fibroblasts were significantly increased in the heat-exposed groups compared to those in the control group. The heat exposed groups strongly increased extracellular matrix collagen accumulation in testicular interstitial tissues. Conclusion: Heat stress adversely affects the testicular structure and spermatogenesis, causes inflammation, and progresses to testicular interstitial fibrosis. |
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| کلیدواژه‌های انگلیسی مقاله |
Heat stress, Testicular, Inflammation, Fibrosis. |
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| نویسندگان مقاله |
| Tung Nguyen-Thanh
Faculty of Basic Science, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam. Institute of Biomedicine, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam.
| Phuoc Dang-Van
Forensic Medicine Center in Thua Thien Hue Province, Hue, Vietnam.
| Phuc Dang-Ngoc
Faculty of Medicine, Dong A University, Da Nang, Vietnam.
| Won Kim
Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju, Republic of Korea.
| Tam Le-Minh
Department of Obstetrics and Gynecology, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam.
| Quoc-Huy Nguyen-Vu
Department of Obstetrics and Gynecology, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam.
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| نشانی اینترنتی |
http://ijrm.ssu.ac.ir/browse.php?a_code=A-10-1820-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Cellular and Molecular Biology of Reproduction |
| نوع مقاله منتشر شده |
Original Article |
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