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Research in Pharmaceutical Sciences، جلد ۱۷، شماره ۳، صفحات ۳۰۵-۳۱۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Further evidence to support acute and chronic anti-inflammatory effects of Nasturtium officinale |
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| چکیده انگلیسی مقاله |
Background and purpose: Previously, we reported the anti-inflammatory properties of Nasturtium officinale (watercress) in several models of acute inflammation. This study was designed to explore the effects of topical and systemic administrations of N. officinale in the two chronic inflammatory models and to evaluate the role of TNF-α and IL-1β in these effects. Experimental approach: Folin-Ciocalteu and aluminum chloride methods were used to estimate the extract's total phenol and flavonoid content, respectively. Carrageenan-induced paw edema was carried out and TNF-α and IL-1β concentrations in the carrageenan-treated paw tissue were determined. Formalin injection into rat hind paws (7 days) and the application of 12-O-tetradecanoyl phorbol-13-acetate (TPA) on mouse ears (9 days) were used to simulate chronic inflammation. Furthermore, a histological assessment of the inflamed tissues was carried out. Findings/Results: The extract's flavonoid and phenolic contents were 90.26 ± 4.81 mg rutin equivalents/g and 68 ± 8.16 gallic acid equivalents/g gallic acid, respectively. N. officinale pretreatment in all doses administered considerably decreased carrageenan-induced edema. The extract also reduced IL-1β levels in carrageenan-treated paws while did not affect TNF-α levels. Oral and topical administrations of N. officinale considerably reserved the paw and ear edema. The extract also ameliorated the tissue injuries due to formalin and TPA challenges. Conclusion and implications: The data confirmed the topical and systemic anti-inflammatory effects of watercress against two chronic models of inflammation. They suggested that these properties are not related to TNF-α but could be attributed to inhibition of IL-1β and inhibition of leukocyte infiltration. |
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| کلیدواژه‌های انگلیسی مقاله |
Anti-inflammatory,Interleukin-1 beta,Nasturtium officinale,Tetradecanoyl phorbol acetate,Tumor necrosis factor-alpha. |
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| نویسندگان مقاله |
| Mostafa Mostafazadeh
3Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, I.R. Iran.
4Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, I.R. Iran.
| Heibatollah Sadeghi
3Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, I.R. Iran.
5Department of Pharmacology, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, I.R. Iran.
| Hossein Sadeghi
6Department of Clinical Biochemistry, Faculty of Medicine, Behbahan University of Medical Sciences,Behbahan, I.R. Iran.
| Vahid Zarezade
4Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, I.R. Iran.
| Abolghasem Hadinia
3Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, I.R. Iran.
| Esmaeel Panahi Kokhdan
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| نشانی اینترنتی |
http://rps.mui.ac.ir/index.php/jrps/article/view/2128 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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