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Avicenna Journal of Medical Biotechnology، جلد ۱۳، شماره ۴، صفحات ۲۲۳-۲۲۵
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Evaluation of miR-222 Expression in HBV Infected Patients in Comparison with HDV and HBV Co-infected Patients |
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| چکیده انگلیسی مقاله |
Background: Liver disease is more severe in HDV+HBV co-infected patients than HBV infected patients which seems to be related to differences in the expression of genes and other factors such as MicroRNAs (miRNAs). The aim of this study was to investigate miR-222 expression in HBV infected patients in comparison with HDV+HBV co-infected patients. Methods: First, total RNA was extracted from the serum samples and then, complementary DNA (cDNA) was produced using cDNA synthesis kit. Finally, miR-222 gene expression was measured using U6 as the internal control by quantitative PCR (qPCR). Results: The level of miR-222 expression in HDV+HBV co-infected samples was significantly up regulated. The fold change of the miR-222 expression between two groups was 3.3 (95% CI; 0.011- 17.63) with p< 0.001. Conclusion: The expression of miR-222 was higher in HBV+HDV co-infected patients than HBV infected patients. Further studies should be conducted to confirm whether miR-222 can be a biomarker for prognosis of severe liver diseases. |
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| کلیدواژه‌های انگلیسی مقاله |
Co-infection with hepatitis B and D, Hepatitis B virus, Hepatitis D virus, MiR-222 |
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| نویسندگان مقاله |
| Zahra Sokhanvar
Department of Microbiology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran
| Ameneh Elikaei
Department of Microbiology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran
| Zohreh Sharifi
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| نشانی اینترنتی |
https://www.ajmb.org/En/Article.aspx?id=40481 |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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