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Avicenna Journal of Medical Biotechnology، جلد ۱۳، شماره ۴، صفحات ۲۰۷-۲۱۶
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Molecular Mechanisms of Anti-inflammatory Activities of the Extracts of Ocimum gratissimum and Thymus vulgaris |
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| چکیده انگلیسی مقاله |
Background: A large body of literature suggests that the extracts of Ocimum gratissimum (O. gratissimum) and Thymus vulgaris (T. vulgaris) play protective roles against various inflammatory disorders. However, the possible mechanism of action with reference to the interactions of their respective phytochemical compositions with pro-inflammatory mediators as the indication of their therapeutic effects is less clear. Therefore, the immunomodulatory properties of O. gratissimum and T. vulgaris were investigated in this study. Methods: The in vitro lipoxygenase inhibitory potentials of methanolic extracts of the selected plants were assessed through colorimetric analysis. The pharmacokinetics of some identified compounds in the botanicals were investigated via the Swiss ADME server while the molecular interactions of the compounds with lipoxygenase, IL-1, IL-6, TNF-α, IL-8, and CCL-2 were performed through molecular docking. Results: The assessment of the lipoxygenase inhibition revealed the extracts could possess anti-inflammatory agents. The pharmacokinetic results of some selected compounds identified in the botanicals showed moderate toxic effects compared to indomethacin. The molecular docking study substantiated the report of the in vitro analysis as indicated in the binding score of all the selected compounds compared to indomethacin. Conclusion: The phytochemical components of the extracts of O. gratissimum and T. vulgaris could be effective as anti-inflammatory agents that could be explored in preventing disorders associated with excessive activities of pro-inflammatory mediators. |
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| کلیدواژه‌های انگلیسی مقاله |
Anti-inflammatory agents, Lipoxygenase, Ocimum, Phytochemicals, Plant extracts, Thymus plant |
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| نویسندگان مقاله |
| Ige Francis Olaoye
Department of Biochemistry, McPherson University, Seriki Sotayo, Ogun State, Nigeria
| Babatunde Joseph Oso
| Adepeju Aberuagba
Department of Biochemistry, University of Ilorin, Ilorin, Kwara State, Nigeria
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| نشانی اینترنتی |
https://www.ajmb.org/En/Article.aspx?id=40479 |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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