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Avicenna Journal of Medical Biotechnology، جلد ۱۴، شماره ۱، صفحات ۱۰-۲۹
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Non-gynaecological Applications of Menstrual-derived Stem Cells: A Systematic Review |
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| چکیده انگلیسی مقاله |
Menstrual-derived Stem Cells (MenSC) are a potential novel source of mesenchymal stem cells. There is an increased interest in investigating the therapeutic potential of MenSC due to the various advantages they exhibit, when compared to other types of stem cells. MenSC are obtained non-invasively from menstrual blood. Thus, collection of MenSC is simple, reproducible and can be carried out periodically, with minimal complications. MenSC are present in abundance, are highly proliferative, exhibit a low immunogenicity and lack ethical issues. MenSC have shown the ability to differentiate into several lineages. The therapeutic potential of MenSC in non-gynaecological applications has been investigated in wound healing, neurological, musculo-skeletal, cardiovascular, respiratory, and liver disorders, as well as in diabetes and cancer. Human clinical trials are limited. To date, therapeutic efficacy and safety have been reported in patients with Avian influenza A subtype H7N9, COVID-19, congestive heart failure, multiple sclerosis and Duchene muscular dystrophy. However, further clinical trials in humans should be conducted, to study the long-term therapeutic effects of these stem cells in various diseases and to further explore their mechanism of action. This systematic review focuses on the application of MenSC in non-gynaecological diseases. |
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| کلیدواژه‌های انگلیسی مقاله |
Cell therapy, Menstruation, Mesenchymal stem cells, Regenerative medicine, Stem cells |
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| نویسندگان مقاله |
| Claire Galea
| Nicoletta Riva
Department of Pathology, Faculty of Medicine and Surgery, University of Malta, Msida, Malta
| Jean Calleja-Agius
Department of Anatomy, Faculty of Medicine and Surgery, University of Malta, Msida, Malta
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| نشانی اینترنتی |
https://www.ajmb.org/En/Article.aspx?id=40490 |
| فایل مقاله |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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